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Inflammation boosts bacteriophage transfer between Salmonella spp.
Swiss Fed Inst Technol, Inst Microbiol, Zurich, Switzerland..
Swiss Fed Inst Technol, Inst Microbiol, Zurich, Switzerland..
Univ Paris Saclay, AgroParisTech, INRA, Micalis Inst, F-78350 Jouy En Josas, France..
Swiss Fed Inst Technol, Inst Microbiol, Zurich, Switzerland..
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2017 (English)In: Science, ISSN 0036-8075, E-ISSN 1095-9203, Vol. 355, no 6330, 1211-1215 p.Article in journal (Refereed) Published
Abstract [en]

Bacteriophage transfer (lysogenic conversion) promotes bacterial virulence evolution. There is limited understanding of the factors that determine lysogenic conversion dynamics within infected hosts. Amurine Salmonella Typhimurium (S.Tm) diarrhea model was used to study the transfer of SopEF, a prophage from S.Tm SL1344, to S.Tm ATCC14028S. Gut inflammation and enteric disease triggered >55% lysogenic conversion of ATCC14028S within 3 days. Without inflammation, SopEF transfer was reduced by up to 10(5)-fold. This was because inflammation (e.g., reactive oxygen species, reactive nitrogen species, hypochlorite) triggers the bacterial SOS response, boosts expression of the phage antirepressor Tum, and thereby promotes free phage production and subsequent transfer. Mucosal vaccination prevented a dense intestinal S.Tm population from inducing inflammation and consequently abolished SopEF transfer. Vaccination may be a general strategy for blocking pathogen evolution that requires disease-driven transfer of temperate bacteriophages.

Place, publisher, year, edition, pages
2017. Vol. 355, no 6330, 1211-1215 p.
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-318917DOI: 10.1126/science.aaf8451ISI: 000396351200045OAI: oai:DiVA.org:uu-318917DiVA: diva2:1087037
Funder
Swedish Research Council, 2012-262, 2015-00635
Available from: 2017-04-05 Created: 2017-04-05 Last updated: 2017-04-05Bibliographically approved

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Sellin, Mikael E.
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