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Association of Pregnancy Complications and Characteristics With Future Risk of Elevated Blood Pressure The Västerbotten Intervention Program
Univ Calif San Francisco, Dept Med, Div Cardiol, San Francisco, CA 94143 USA..
Umea Univ, Dept Publ Hlth & Clin Med, Epidemiol & Global Hlth, S-90187 Umea, Sweden..
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Molecular epidemiology. Uppsala University, Science for Life Laboratory, SciLifeLab. Stanford Univ, Dept Med, Div Cardiovasc Med, Sch Med, Stanford, CA 94305 USA..ORCID iD: 0000-0003-2256-6972
Karolinska Inst, Dept Med Solna, Clin Epidemiol Unit, Stockholm, Sweden..
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2017 (English)In: Hypertension, ISSN 0194-911X, E-ISSN 1524-4563, Vol. 69, no 3, 475-483 p.Article in journal (Refereed) Published
Abstract [en]

Pregnancy characteristics are associated with risk of cardiovascular diseases, but their independent associations with hypertension or blood pressure (BP) levels remain uncertain. We linked the Swedish Medical Birth Register with Vesterbotten Intervention Program data (Northern Sweden). Using linear and logistic regression, we related pregnancy factors in any prior pregnancy with BP and hypertension at 40 years of age in 15 896 parous women free of prepregnancy hypertension. Pregnancy factors included parity, age at first delivery, preeclampsia, gestational diabetes mellitus, placental abruption, shortest gestational age small for gestational age baby (<third percentile for birth weight) or stillbirth. We defined hypertension as systolic BP >= 140 mm Hg and diastolic BP >= 90 mm Hg or antihypertensive use. Multivariable models were adjusted for all pregnancy factors and potential lifestyle and sociodemographic confounders. At 40 years of age, 1535 women (9.6%) had hypertension. In multivariable models, lower parity, younger age at first birth, preeclampsia, small for gestational age, and placental abruption were independently associated with higher systolic and diastolic BP levels at 40 years of age. Younger age at first birth, preeclampsia, gestational age <32 versus >= 37 weeks, and small for gestational age were independently associated with hypertension. Our findings raise the possibility that earlier and more frequent BP screening may be desirable in women with these pregnancy characteristics.

Place, publisher, year, edition, pages
LIPPINCOTT WILLIAMS & WILKINS , 2017. Vol. 69, no 3, 475-483 p.
Keyword [en]
blood pressure, hypertension, preeclampsia, pregnancy complications, preterm birth, women
National Category
Obstetrics, Gynecology and Reproductive Medicine
Identifiers
URN: urn:nbn:se:uu:diva-319546DOI: 10.1161/HYPERTENSIONAHA.116.08121ISI: 000394323100017PubMedID: 28137991OAI: oai:DiVA.org:uu-319546DiVA: diva2:1087226
Funder
NIH (National Institute of Health), R21 7R21HL115398Forte, Swedish Research Council for Health, Working Life and Welfare, 2010-0643
Available from: 2017-04-06 Created: 2017-04-06 Last updated: 2017-04-06Bibliographically approved

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