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Serum Biomarkers of Myocardial Remodeling and Coronary Dysfunction in Early Stages of Hypertrophic Cardiomyopathy in the Young.
Lund Univ, Skane Univ Hosp, Pediat Heart Ctr, Lund, Sweden.; Linkoping Univ, Linkoping Univ Hosp, Dept Paediat, Linkoping, Sweden.
Lund Univ, Univ Lund Hosp, Dept Clin Sci, Lund, Sweden.
Lund Univ, Univ Lund Hosp, Dept Clin Sci, Lund, Sweden.
Lund Univ, Univ Lund Hosp, Dept Clin Sci, Lund, Sweden.
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2017 (English)In: Pediatric Cardiology, ISSN 0172-0643, E-ISSN 1432-1971, Vol. 38, no 4, 853-863 p.Article in journal (Refereed) Published
Abstract [en]

Hypertrophic cardiomyopathy (HCM) remains the leading cause of sudden cardiac death in the young. Early markers for HCM are important to identify individuals at risk. The aim of this study was to investigate novel serum biomarkers reflecting myocardial remodeling, microfibrosis, and vascular endotheliopathy in the early stages of familial HCM in young patients. Twenty-three HCM patients, 16 HCM-risk individuals, and 66 controls (median 15 years) underwent echocardiography and serum analysis for cathepsin S, endostatin, myostatin, type I collagen degradation marker (ICTP), matrix metalloproteinase (MMP)-9, vascular endothelial growth factor receptor (VEGFR)-1, and vascular and intercellular adhesion molecules (VCAM, ICAM). In a subset of the population, global myocardial perfusion was performed by magnetic resonance imaging. Cathepsin S (p = 0.0009), endostatin (p < 0.0001), MMP-9 (p = 0.008), and VCAM (p = 0.04) were increased in the HCM group and correlated to left ventricular mass index and mitral E/e' (p < 0.01). In the HCM-risk group, myostatin was decreased (p = 0.004), whereas ICAM was increased (p = 0.002). Global perfusion was decreased in the HCM group (p < 0.05) versus controls. Endostatin and mitral E/e' correlated inversely to myocardial perfusion (p ≤ 0.05). This is the first study demonstrating adverse changes in biomarkers reflecting myocardial matrix remodeling, microfibrosis, and vascular endotheliopathy in early stage of hypertrophic cardiomyopathy in the young.

Place, publisher, year, edition, pages
2017. Vol. 38, no 4, 853-863 p.
Keyword [en]
Biomarkers, Early stage, Hypertrophic cardiomyopathy, Myocardium, Risk
National Category
Cardiac and Cardiovascular Systems
Identifiers
URN: urn:nbn:se:uu:diva-319728DOI: 10.1007/s00246-017-1593-xISI: 000399219800027PubMedID: 28361263OAI: oai:DiVA.org:uu-319728DiVA: diva2:1087487
Available from: 2017-04-07 Created: 2017-04-07 Last updated: 2017-05-18Bibliographically approved

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