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Divergent evolution of life span associated with mitochondrial DNA evolution
Univ Belgrade, Inst Zool, Fac Biol, Studentski Trg 16, Belgrade 11000, Serbia.;Univ Belgrade, Inst Biol Res Sinisa Stankovic, Dept Evolutionary Biol, Despota Stefana Blvd 142, Belgrade 11060, Serbia..
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Genetics, Animal ecology.
Univ Belgrade, Inst Biol Res Sinisa Stankovic, Dept Evolutionary Biol, Despota Stefana Blvd 142, Belgrade 11060, Serbia..
Inst Plant Protect & Environm, Dept Plant Pests, Banatska 33, Zemun 11080, Serbia..
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2017 (English)In: Evolution, ISSN 0014-3820, E-ISSN 1558-5646, Vol. 71, no 1, 160-166 p.Article in journal (Refereed) Published
Abstract [en]

Mitochondria play a key role in ageing. The pursuit of genes that regulate variation in life span and ageing have shown that several nuclear-encoded mitochondrial genes are important. However, the role of mitochondrial encoded genes (mtDNA) is more controversial and our appreciation of the role of mtDNA for the evolution of life span is limited. We use replicated lines of seed beetles that have been artificially selected for long or short life for >190 generations, now showing dramatic phenotypic differences, to test for a possible role of mtDNA in the divergent evolution of ageing and life span. We show that these divergent selection regimes led to the evolution of significantly different mtDNA haplotype frequencies. Selection for a long life and late reproduction generated positive selection for one specific haplotype, which was fixed in most such lines. In contrast, selection for reproduction early in life led to both positive selection as well as negative frequency-dependent selection on two different haplotypes, which were both present in all such lines. Our findings suggest that the evolution of life span was in part mediated by mtDNA, providing support for the emerging general tenet that adaptive evolution of life-history syndromes may involve mtDNA.

Place, publisher, year, edition, pages
WILEY-BLACKWELL , 2017. Vol. 71, no 1, 160-166 p.
Keyword [en]
Acanthoscelides obtectus, artificial selection, Bruchinae, coadaptation, mitochondria, mtDNA, negative frequency dependent selection, senescence
National Category
Genetics
Identifiers
URN: urn:nbn:se:uu:diva-319809DOI: 10.1111/evo.13102ISI: 000394439600014PubMedID: 27778315OAI: oai:DiVA.org:uu-319809DiVA: diva2:1087868
Funder
EU, European Research Council, GENCON AdG-294333Swedish Research Council, 621-2010-5266
Available from: 2017-04-10 Created: 2017-04-10 Last updated: 2017-04-10Bibliographically approved

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