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Targeting SOX9 for degradation to inhibit chemoresistance, metastatic spread, and recurrence
Karolinska Inst, Dept Cell & Mol Biol, Stockholm, Sweden..
Uppsala University, Science for Life Laboratory, SciLifeLab. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Neuro-Oncology.ORCID iD: 0000-0002-8460-4367
Karolinska Inst, Dept Cell & Mol Biol, Stockholm, Sweden..
2017 (English)In: Molecular & cellular oncology, ISSN 2372-3556, Vol. 4, no 1, e1252871Article in journal (Refereed) Published
Abstract [en]

Cancer cells with stem-like properties are believed to contribute to treatment resistance, dissemination, and recurrence. SOX9 controls stem cell plasticity and its deregulation may provide a basis for tumor progression. Here, we summarize our findings of targeted SOX9 destruction by SCFFBW7 (Skp1/Cul1/F-box) in medulloblastoma and its potential for therapeutic intervention.

Place, publisher, year, edition, pages
Taylor & Francis, 2017. Vol. 4, no 1, e1252871
Keyword [en]
Drug resistance, FBW7, medulloblastoma, metastasis, SCF ubiquitin ligase, SOX9
National Category
Cancer and Oncology
Identifiers
URN: urn:nbn:se:uu:diva-319299DOI: 10.1080/23723556.2016.1252871ISI: 000396558100010OAI: oai:DiVA.org:uu-319299DiVA: diva2:1088157
Funder
Swedish Childhood Cancer FoundationSwedish Cancer SocietySwedish Research CouncilEU, European Research CouncilRagnar Söderbergs stiftelseSwedish Society of MedicineÅke Wiberg FoundationScience for Life Laboratory - a national resource center for high-throughput molecular bioscienceThe Karolinska Institutet's Research Foundation
Available from: 2017-04-11 Created: 2017-04-11 Last updated: 2017-04-20Bibliographically approved

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Swartling, Fredrik J.
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