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Neurovascular Bundle Infiltration Can Explain Local Relapses Using Conformal Radiotherapy of Prostate Cancer.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Centrum för klinisk forskning i Sörmland (CKFD). Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Medical Radiation Science.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Medical Radiation Science.
2017 (English)In: Anticancer Research, ISSN 0250-7005, E-ISSN 1791-7530, Vol. 37, no 4, p. 1825-1830Article in journal (Refereed) Published
Abstract [en]

AIM: To quantify the impact of decreased margins for two treatment techniques, three-dimensional conformal radiotherapy (3D-CRT) and volumetric-modulated arc therapy (VMAT), on local control in curative treatment of prostate cancer.

MATERIALS AND METHODS: The planning target volume (PTV) margins were decreased in steps of 1 mm from 10 to 1 mm. Treatment plans using 3D-CRT and VMAT technique were produced for all margin sizes and the dose to the neuro vascular bundles (NVB), that was not included in the PTV, was investigated.

RESULTS: Due to the more conformal dose delivery using VMAT, the dose to the NVB decreased more rapidly by VMAT compared to the 3D-CRT plans. The dose difference was significant for margins from 1-7 mm.

CONCLUSION: One should be very cautious before clinical routines are changed, bearing in mind whether the change means more conformal treatment technique, smaller margins or target segmentation in different imaging modalities.

Place, publisher, year, edition, pages
2017. Vol. 37, no 4, p. 1825-1830
Keyword [en]
3D-CRT, Prostate cancer, VMAT, local relapse, radiotherapy
National Category
Cancer and Oncology
Identifiers
URN: urn:nbn:se:uu:diva-320017DOI: 10.21873/anticanres.11517ISI: 000402167700035PubMedID: 28373447OAI: oai:DiVA.org:uu-320017DiVA: diva2:1088496
Available from: 2017-04-12 Created: 2017-04-12 Last updated: 2017-07-14Bibliographically approved

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Johansson, Andreas K.Isacsson, Ulf

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Centrum för klinisk forskning i Sörmland (CKFD)Medical Radiation Science
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