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Computational fluid dynamics (CFD) studies of a miniaturized dissolution system
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmacy.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmacy.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmacy.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmacy.
2017 (English)In: International Journal of Pharmaceutics, ISSN 0378-5173, E-ISSN 1873-3476, Vol. 521, no 1-2, 274-281 p.Article in journal (Refereed) Published
Abstract [en]

Dissolution testing is an important tool that has applications ranging from fundamental studies of drugrelease mechanisms to quality control of the final product. The rate of release of the drug from the delivery system is known to be affected by hydrodynamics. In this study we used computational fluid dynamics to simulate and investigate the hydrodynamics in a novel miniaturized dissolution method for parenteral formulations. The dissolution method is based on a rotating disc system and uses a rotating sample reservoir which is separated from the remaining dissolution medium by a nylon screen. Sample reservoirs of two sizes were investigated (SR6 and SR8) and the hydrodynamic studies were performed at rotation rates of 100, 200 and 400 rpm. The overall fluid flow was similar for all investigated cases, with a lateral upward spiraling motion and central downward motion in the form of a vortex to and through the screen. The simulations indicated that the exchange of dissolution medium between the sample reservoir and the remaining release medium was rapid for typical screens, for which almost complete mixing would be expected to occur within less than one minute at 400 rpm. The local hydrodynamic conditions in the sample reservoirs depended on their size; SR8 appeared to be relatively more affected than SR6 by the resistance to liquid flow resulting from the screen.

Place, publisher, year, edition, pages
ELSEVIER SCIENCE BV , 2017. Vol. 521, no 1-2, 274-281 p.
Keyword [en]
Computational fluid dynamics, Miniaturized dissolution testing, Drug-release mechanisms
National Category
Pharmaceutical Sciences
Identifiers
URN: urn:nbn:se:uu:diva-320019DOI: 10.1016/j.ijpharm.2017.01.072ISI: 000397613700031PubMedID: 28189856OAI: oai:DiVA.org:uu-320019DiVA: diva2:1088638
Funder
Swedish Research Council, 521-2011-3773
Available from: 2017-04-13 Created: 2017-04-13 Last updated: 2017-04-13Bibliographically approved

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Frenning, GöranAhnfelt, EmelieSjögren, ErikLennernäs, Hans
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