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Electrical detection of nucleotides via nanopores in a hybrid graphene/h-BN sheet
Fed Inst Educ Sci & Technol Espirito Santo IFES, Ibatiba, ES, Brazil.;Univ Fed Espirito Santo, Dept Fis, Vitoria, ES, Brazil..
UFF, ICEx, Dept Fis, Volta Redonda, RJ, Brazil..
Univ Fed Espirito Santo, Dept Fis, Vitoria, ES, Brazil..
Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Materials Theory.
2017 (English)In: Nanoscale, ISSN 2040-3364, E-ISSN 2040-3372, Vol. 9, no 6, 2207-2212 p.Article in journal (Refereed) Published
Abstract [en]

Designing the next generation of solid-state biosensors requires developing detectors which can operate with high precision at the single-molecule level. Nano-scaled architectures created in two-dimensional hybrid materials offer unprecedented advantages in this regard. Here, we propose and explore a novel system comprising a nanopore formed within a hybrid sheet composed of a graphene nanoroad embedded in a sheet of hexagonal boron nitride (h-BN). The sensitive element of this setup is comprised of an electrically conducting carbon chain forming one edge of the nanopore. This design allows detection of DNA nucleotides translocating through the nanopore based on the current modulation signatures induced in the carbon chain. In order to assess whether this approach is feasible to distinguish the four different nucleotides electrically, we have employed density functional theory combined with the nonequilibrium Green's function method. Our findings show that the current localized in the carbon chain running between the nanopore and h-BN is characteristically modulated by the unique dipole moment of each molecule upon insertion into the pore. Through the analysis of a simple model based on the dipole properties of the hydrogen fluoride molecule we are able to explain the obtained findings.

Place, publisher, year, edition, pages
ROYAL SOC CHEMISTRY , 2017. Vol. 9, no 6, 2207-2212 p.
National Category
Natural Sciences
Identifiers
URN: urn:nbn:se:uu:diva-319864DOI: 10.1039/c6nr07154fISI: 000395626600014PubMedID: 28120993OAI: oai:DiVA.org:uu-319864DiVA: diva2:1088661
Funder
Carl Tryggers foundation Swedish Research Council
Available from: 2017-04-13 Created: 2017-04-13 Last updated: 2017-04-13Bibliographically approved

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CiteExportLink to record
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