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Sex-specific mitonuclear epistasis and the evolution of mitochondrial bioenergetics, ageing, and life history in seed beetles
Univ Belgrade, Inst Biol Res, Dept Evolutionary Biol, Despota Stefana Blvd 142, Belgrade 11060, Serbia..
Univ Belgrade, Inst Biol Res, Dept Evolutionary Biol, Despota Stefana Blvd 142, Belgrade 11060, Serbia.;Univ Belgrade, Fac Biol, Inst Zool, Studentskitrg 16, Belgrade 11000, Serbia..
Univ Belgrade, Inst Biol Res, Dept Evolutionary Biol, Despota Stefana Blvd 142, Belgrade 11060, Serbia..
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Genetics, Animal ecology.ORCID iD: 0000-0003-1121-6950
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2017 (English)In: Evolution, ISSN 0014-3820, E-ISSN 1558-5646, Vol. 71, no 2, p. 274-288Article in journal (Refereed) Published
Abstract [en]

The role of mitochondrial DNA for the evolution of life-history traits remains debated. We examined mitonuclear effects on the activity of the multisubunit complex of the electron transport chain (ETC) involved in oxidative phosphorylation (OXPHOS) across lines of the seed beetle Acanthoscelides obtectus selected for a short (E) or a long (L) life for more than >160 generations. We constructed and phenotyped mitonuclear introgression lines, which allowed us to assess the independent effects of the evolutionary history of the nuclear and the mitochondrial genome. The nuclear genome was responsible for the largest share of divergence seen in ageing. However, the mitochondrial genome also had sizeable effects, which were sex-specific and expressed primarily as epistatic interactions with the nuclear genome. The effects of mitonuclear disruption were largely consistent with mitonuclear coadaptation. Variation in ETC activity explained a large proportion of variance in ageing and life-history traits and this multivariate relationship differed somewhat between the sexes. In conclusion, mitonuclear epistasis has played an important role in the laboratory evolution of ETC complex activity, ageing, and life histories and these are closely associated. The mitonuclear architecture of evolved differences in life-history traits and mitochondrial bioenergetics was sex-specific.

Place, publisher, year, edition, pages
WILEY , 2017. Vol. 71, no 2, p. 274-288
Keywords [en]
Bruchinae, coadaptation, epistasis, evolution of ageing, mitochondria, mtDNA, OXPHOS, senescence, sexual dimorphism
National Category
Ecology Evolutionary Biology
Identifiers
URN: urn:nbn:se:uu:diva-320716DOI: 10.1111/evo.13109ISI: 000394985200007PubMedID: 27861795OAI: oai:DiVA.org:uu-320716DiVA, id: diva2:1090443
Funder
EU, European Research Council, AdG-294333Swedish Research Council, 621-2014-4523Available from: 2017-04-24 Created: 2017-04-24 Last updated: 2018-08-10Bibliographically approved

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Immonen, ElinaArnqvist, Göran

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