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Hypothesis: Homologous Recombination Depends on Parallel Search
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Cell and Molecular Biology, Molecular Systems Biology. Uppsala University, Science for Life Laboratory, SciLifeLab.
2016 (English)In: CELL SYSTEMS, ISSN 2405-4712, Vol. 3, no 4, p. 325-327Article in journal, Editorial material (Refereed) Published
Abstract [en]

It is not known how a cell manages to find a specific DNA sequence sufficiently fast to repair a broken chromosome through homologous recombination. I propose a solution based on freely diffusing molecules that are programmed with sequences corresponding to those flanking the break site. In such a process, the target search would be parallelized.

Place, publisher, year, edition, pages
CELL PRESS , 2016. Vol. 3, no 4, p. 325-327
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Cell and Molecular Biology
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URN: urn:nbn:se:uu:diva-320106DOI: 10.1016/j.cels.2016.10.005ISI: 000395781400004PubMedID: 27788356OAI: oai:DiVA.org:uu-320106DiVA, id: diva2:1090671
Available from: 2017-04-25 Created: 2017-04-25 Last updated: 2018-01-13Bibliographically approved

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Elf, Johan

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