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Parental Attitudes About Placebo Use in Children
Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Psychology. Harvard Med Sch, Ctr Pain & Brain, Dept Anesthesiol Perioperat & Pain Med, Boston Childrens Hosp, Boston, MA USA.;Beth Israel Deaconess Med Ctr, Program Placebo Studies, Boston, MA 02215 USA..
Beth Israel Deaconess Med Ctr, Program Placebo Studies, Boston, MA 02215 USA.;Harvard Med Sch, Dept Anesthesiol Perioperat & Pain Med, Boston Childrens Hosp, Boston, MA USA.;Univ Basel, Dept Clin Psychol & Psychotherapy, Basel, Switzerland..
Harvard Med Sch, Ctr Pain & Brain, Dept Anesthesiol Perioperat & Pain Med, Boston Childrens Hosp, Boston, MA USA..
Beth Israel Deaconess Med Ctr, Program Placebo Studies, Boston, MA 02215 USA..
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2017 (English)In: Journal of Pediatric Surgery Case Reports, ISSN 0022-3476, E-ISSN 2213-5766, Vol. 181, p. 272-+Article in journal (Refereed) Published
Abstract [en]

Objective To assess parental attitudes regarding placebo use in pediatric randomized controlled trials and clinical care. Study design Parents with children under age 18 years living in the US completed and submitted an online survey between September and November 2014. Results Among all 1300 participants, 1000 (76.9%; 538 mothers and 462 fathers) met the study inclusion criteria. The majority of surveyed parents considered the use of placebos acceptable in some pediatric care situations (86%) and some pediatric trials (91.5%), whereas only 5.7% of parents found the use of placebos in children always unacceptable. The clinical use of placebo was considered acceptable by a majority of parents for only 7 (mostly psychological) of the 17 conditions presented. Respondents' judgment about acceptability was influenced by the doctors' opinions about the therapeutic benefits of placebo treatment, the conditions for pediatric placebo use, transparency, safety, and purity of placebos. Conclusion Most surveyed parents accepted the idea of using placebos in pediatric trials and within the clinic for some conditions without the practice of deception and with the creation of guidelines for ethical and safe use. This study suggests a need to reconsider pediatric trial design and clinical therapy in the light of generally positive parental support of appropriate placebo use.

Place, publisher, year, edition, pages
MOSBY-ELSEVIER , 2017. Vol. 181, p. 272-+
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Pediatrics
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URN: urn:nbn:se:uu:diva-320772DOI: 10.1016/j.jpeds.2016.10.018ISI: 000396249200043PubMedID: 27863847OAI: oai:DiVA.org:uu-320772DiVA, id: diva2:1090785
Funder
Swedish Research Council, 437-2014-6767NIH (National Institute of Health), 2k24 AT004095Available from: 2017-04-25 Created: 2017-04-25 Last updated: 2017-04-25Bibliographically approved

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