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Cholesterol uptake in the mouse aorta increases during Chlamydia pneumoniae infection
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Infectious Diseases.
Swedish Univ Agr Sci, Dept Biomed Sci & Vet Publ Hlth, S-75007 Uppsala, Sweden..
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Infectious Diseases.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Infectious Diseases. Natl Food Agcy, Risk Benefit Assessment Dept, S-75126 Uppsala, Sweden..
2017 (English)In: Pathogens and Disease, E-ISSN 2049-632X, Vol. 75, no 1, article id ftx004Article in journal (Refereed) Published
Abstract [en]

Chlamydia pneumoniae has been suggested as a stimulator of the atherosclerotic process. Mice fed a normal diet were infected intranasally with C. pneumoniae and given one intraperitoneal injection of C-14-cholesterol tracer per day for 12 days. Bacteria were demonstrated in the aorta in the early phase of infection and in lungs and liver throughout the study period of 20 days. C-14-cholesterol was not affected in the heart but increased in the blood, liver and aorta on day 4 when the infection was clinically most severe. Furthermore, on day 20 C-14-cholesterol tended to be increased in the aorta. Accordingly, copper-and zinc levels and expressions of the infection biomarkers Cxcl2 and Ifng increased in the liver on day 4 with a tendency of increased of copper, zinc and Ifng on day 20. In mice where bacteria could be cultivated from the lungs, expressions of cholesterol transporters Abca1 and Idol were both increased in the liver on day 4. The increased levels of C-14-cholesterol in blood and aorta together with increased Abca1 and Idol in the liver during C. pneumoniae infection in mice fed a normal diet suggest that this pathogen may have a role in the initiation of the atherosclerotic process.

Place, publisher, year, edition, pages
OXFORD UNIV PRESS , 2017. Vol. 75, no 1, article id ftx004
Keywords [en]
Chlamydia pneumoniae, atherosclerosis, cholesterol, Idol, Abca1, Cxcl2, interferon gamma, mouse, copper, zinc
National Category
Infectious Medicine
Identifiers
URN: urn:nbn:se:uu:diva-320821DOI: 10.1093/femspd/ftx004ISI: 000398086700008PubMedID: 28158541OAI: oai:DiVA.org:uu-320821DiVA, id: diva2:1091125
Funder
Swedish Research Council FormasAvailable from: 2017-04-26 Created: 2017-04-26 Last updated: 2017-11-29Bibliographically approved

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Edvinsson, MarieNyström-Rosander, ChristinaIlbäck, Nils-Gunnar

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