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Heparin-coated cardiopulmonary bypass circuits reduce circulating complement factors and interleukin-6 in paediatric heart surgery
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences. (Thoracic Surgery)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology. (Coagulation Research)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences. (Thoracic Surgery)
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology. (KITM)
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2000 (English)In: Scandinavian Cardiovascular Journal, ISSN 1401-7431, E-ISSN 1651-2006, Vol. 34, no 1, 33-40 p.Article in journal (Refereed) Published
Abstract [en]

Children are sensitive to the inflammatory side effects of cardiopulmonary bypass (CPB). Our intention was to investigate if the biocompatibility benefits of heparin-coated CPB circuits apply to children. In 20 operations, 19 children were randomized to heparin-coated (group HC, n = 10) or standard (group C, n = 10) bypass circuits. Plasma levels of acute phase reactants, interleukins, granulocytic proteins and complement factors were measured. All were significantly elevated after CPB. Levels of complement factor C3a (851 (791-959)ng/ml [median with quartiles] in group C, 497 (476-573)ng/ml in group HC, p < 0.001), Terminal Complement Complex (114 (71-130) AU/ml in group C, 35.5 (28.9-51.4) AU/ml in group HC, p < 0.001), and interleukin-6 (570 (203-743) pg/ml in group C, 168 (111-206)pg/ml in group HC, p = 0.005), were significantly reduced in group HC. Heparin-coated CPB circuits improve the biocompatibility of CPB during heart surgery in the paediatric patient population, as reflected by significantly reduced levels of circulating complement factors and interleukin-6.

Place, publisher, year, edition, pages
2000. Vol. 34, no 1, 33-40 p.
Keyword [en]
Anticoagulants/pharmacology, Antithrombin III/metabolism, Biological Markers/blood, C-Reactive Protein/metabolism, Cardiopulmonary Bypass/*instrumentation, Coated Materials; Biocompatible, Comparative Study, Complement C3/antagonists & inhibitors/*metabolism, Complement Membrane Attack Complex/antagonists & inhibitors/metabolism, Enzyme-Linked Immunosorbent Assay, Heart Defects; Congenital/blood/*surgery, Heparin/pharmacology, Humans, Infant, Interleukin-10/blood, Interleukin-6/antagonists & inhibitors/*blood, Interleukin-8/blood, Lactoferrin/blood, Peptide Hydrolases/metabolism, Peroxidase/blood, Prospective Studies, Research Support; Non-U.S. Gov't, Treatment Outcome
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Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-81272PubMedID: 10816058OAI: oai:DiVA.org:uu-81272DiVA: diva2:109187
Available from: 2006-07-21 Created: 2006-07-21 Last updated: 2017-12-14Bibliographically approved

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Olsson, ChristianSiegbahn, AgnetaNilsson, BoVenge, PerJoachimsson, Per-OlofThelin, Stefan

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