Heparin-coated cardiopulmonary bypass circuits reduce circulating complement factors and interleukin-6 in paediatric heart surgery
2000 (English)In: Scandinavian Cardiovascular Journal, ISSN 1401-7431, Vol. 34, no 1, 33-40 p.Article in journal (Refereed) Published
Children are sensitive to the inflammatory side effects of cardiopulmonary bypass (CPB). Our intention was to investigate if the biocompatibility benefits of heparin-coated CPB circuits apply to children. In 20 operations, 19 children were randomized to heparin-coated (group HC, n = 10) or standard (group C, n = 10) bypass circuits. Plasma levels of acute phase reactants, interleukins, granulocytic proteins and complement factors were measured. All were significantly elevated after CPB. Levels of complement factor C3a (851 (791-959)ng/ml [median with quartiles] in group C, 497 (476-573)ng/ml in group HC, p < 0.001), Terminal Complement Complex (114 (71-130) AU/ml in group C, 35.5 (28.9-51.4) AU/ml in group HC, p < 0.001), and interleukin-6 (570 (203-743) pg/ml in group C, 168 (111-206)pg/ml in group HC, p = 0.005), were significantly reduced in group HC. Heparin-coated CPB circuits improve the biocompatibility of CPB during heart surgery in the paediatric patient population, as reflected by significantly reduced levels of circulating complement factors and interleukin-6.
Place, publisher, year, edition, pages
2000. Vol. 34, no 1, 33-40 p.
Anticoagulants/pharmacology, Antithrombin III/metabolism, Biological Markers/blood, C-Reactive Protein/metabolism, Cardiopulmonary Bypass/*instrumentation, Coated Materials; Biocompatible, Comparative Study, Complement C3/antagonists & inhibitors/*metabolism, Complement Membrane Attack Complex/antagonists & inhibitors/metabolism, Enzyme-Linked Immunosorbent Assay, Heart Defects; Congenital/blood/*surgery, Heparin/pharmacology, Humans, Infant, Interleukin-10/blood, Interleukin-6/antagonists & inhibitors/*blood, Interleukin-8/blood, Lactoferrin/blood, Peptide Hydrolases/metabolism, Peroxidase/blood, Prospective Studies, Research Support; Non-U.S. Gov't, Treatment Outcome
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:uu:diva-81272PubMedID: 10816058OAI: oai:DiVA.org:uu-81272DiVA: diva2:109187