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Chlamydia pneumoniae infection predicts a reduced risk for subsequent atopic disease.
Uppsala University, Interfaculty Units, Centrum för klinisk forskning, Gävleborg. Medicinska vetenskapsområdet, Faculty of Medicine, Department of Women's and Children's Health. (Övrig pedriatisk forskning/Nordvall)
Medicinska vetenskapsområdet, Faculty of Medicine, Department of Women's and Children's Health. (Övrig pedriatisk forskning/Nordvall)
2005 (English)In: Acta Paediatr, ISSN 0803-5253, Vol. 94, no 6, 705-10 p.Article in journal (Refereed) Published
Abstract [en]

AIM: To investigate long-term effects on children previously infected with Chlamydia pneumoniae. METHODS: A follow-up questionnaire was sent to all participants from a former population-based study in order to investigate health status during the 4 y that had elapsed between the two studies. In the original study, the prevalence of C. pneumoniae infection was 23% as determined by PCR analyses on throat swab specimens. These PCR results were found to have no detectable correlation for clinical disease. The main outcome measures in this follow-up study were the reported prevalence of respiratory tract infections, asthma and allergy. RESULTS: Approximately 83% completed the follow-up questionnaire. No increase in respiratory tract infections was reported by children previously found to have C. pneumoniae infection. A diagnosis of allergy was more common in the former PCR-negative population (13.4% vs 4.7%, p<0.03). The differences were most apparent in the population with atopic heredity. In a logistic regression model with different suggested risk factors for allergy, earlier infection with C. pneumoniae reduced the risk for allergy (OR=0.13; 95% CI: 0.02-0.99). This was not found for asthma. CONCLUSION: A positive PCR test for C. pneumoniae in young children was associated with a lower risk of developing allergic airway disease in this study population, and did not predict an increase in respiratory tract infections.

Place, publisher, year, edition, pages
2005. Vol. 94, no 6, 705-10 p.
Keyword [en]
Asthma/epidemiology, Child, Chlamydia Infections, Chlamydophila pneumoniae, Female, Follow-Up Studies, Humans, Male, Polymerase Chain Reaction, Prevalence, Questionnaires, Research Support; Non-U.S. Gov't, Respiratory Hypersensitivity/*epidemiology, Respiratory Tract Infections/epidemiology, Risk Factors
Identifiers
URN: urn:nbn:se:uu:diva-81288PubMedID: 16188772OAI: oai:DiVA.org:uu-81288DiVA: diva2:109203
Available from: 2007-03-07 Created: 2007-03-07 Last updated: 2011-01-12

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Normann, ErikWettergren, Björn

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Centrum för klinisk forskning, GävleborgDepartment of Women's and Children's Health

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