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Activated protein C resistance due to factor V Leiden, elevated coagulation factor VIII and postoperative deep vein thrombosis in late breast reconstruction with a free TRAM flap: a report of two cases.
Uppsala University, Interfaculty Units, Centrum för klinisk forskning, Gävleborg.
Uppsala University, Interfaculty Units, Centrum för klinisk forskning, Gävleborg.
2005 (English)In: Br J Plast Surg, ISSN 0007-1226, Vol. 58, no 5, 720-3 p.Article in journal (Refereed) Published
Abstract [en]

Thromboembolic complications can endanger free flap surgery and cause postoperative morbidity and even mortality. The underlying cause of thrombosis is multifactorial; major surgery may trigger hereditary thrombophilic disorders leading to overt thrombotic events. This paper reports two cases with postoperative deep vein thrombosis after late breast reconstruction with a TRAM flap. Both showed APC resistance due to factor V Leiden and elevated coagulation factor VIII. One of the patients also had an event of both arterial and venous anastomotic thrombosis postoperatively.

Place, publisher, year, edition, pages
2005. Vol. 58, no 5, 720-3 p.
Keyword [en]
Activated Protein C Resistance/blood/*complications, Adult, Factor V/*analysis, Factor VIII/*analysis, Female, Humans, Mammaplasty, Middle Aged, Postoperative Complications, Surgical Flaps, Venous Thrombosis/blood/*etiology
Identifiers
URN: urn:nbn:se:uu:diva-81320PubMedID: 15992531OAI: oai:DiVA.org:uu-81320DiVA: diva2:109235
Available from: 2006-08-15 Created: 2006-08-15 Last updated: 2011-01-12

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Olsson, Eija

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