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The involvement of spinal release of histamine on nociceptive behaviors induced by intrathecally administered spermine
Tohoku Med & Pharmaceut Univ, Fac Pharmaceut Sci, Dept Physiol & Anat, Aoba Ku, 4-4-1 Komatsushima, Sendai, Miyagi 9818558, Japan..
Tohoku Med & Pharmaceut Univ, Fac Pharmaceut Sci, Dept Physiol & Anat, Aoba Ku, 4-4-1 Komatsushima, Sendai, Miyagi 9818558, Japan..
Tohoku Med & Pharmaceut Univ, Fac Pharmaceut Sci, Dept Pharmaceut Sci, Aoba Ku, 4-4-1 Komatsushima, Sendai, Miyagi 9818558, Japan..
Tohoku Med & Pharmaceut Univ, Fac Pharmaceut Sci, Dept Physiol & Anat, Aoba Ku, 4-4-1 Komatsushima, Sendai, Miyagi 9818558, Japan..
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2017 (English)In: European Journal of Pharmacology, ISSN 0014-2999, E-ISSN 1879-0712, Vol. 800, 9-15 p.Article in journal (Refereed) Published
Abstract [en]

The involvement of spinal release of histamine on nociceptive behaviors induced by spermine was examined in mice. Intrathecal spermine produced dose-dependent nociceptive behaviors, consisting of scratching, biting and licking. The nociceptive behaviors induced by spermine at 0.02 amol and 10 pmol were markedly suppressed by i.t. pretreatment with antiserum against histamine and were abolished in histidine decarboxylase-deficient mice. In histamine H-1 receptor-deficient mice, the nociceptive behaviors induced by spermine were completely abolished after treatment with 0.02 amol of spermine and significantly suppressed after treatment with 10 pmol of spermine. The i.t. pretreatment with takykinin NK1 receptor antagonists eliminated the nociceptive behaviors induced by 0.02 amol of spermine, but did not affect the nociceptive behaviors induced by 10 pmol of spermine. On the other hand, the nociceptive behaviors induced by spermine at both 0.02 amol and 10 pmol were suppressed by i.t. pretreatment with antagonists for the NMDA receptor polyamine-binding site. The present results suggest that the nociceptive behaviors induced by i.t. administration of spermine are mediated through the spinal release of histamine and are elicited via activation of NMDA receptors.

Place, publisher, year, edition, pages
2017. Vol. 800, 9-15 p.
Keyword [en]
Spermine, Histamine, Release, NMDA receptor, Nociception, Spinal cord
National Category
Pharmacology and Toxicology
Identifiers
URN: urn:nbn:se:uu:diva-321182DOI: 10.1016/j.ejphar.2017.01.031ISI: 000397698800002PubMedID: 28131781OAI: oai:DiVA.org:uu-321182DiVA: diva2:1092418
Available from: 2017-05-02 Created: 2017-05-02 Last updated: 2017-05-02

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Watanabe, Hiroyuki

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