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Transthyretin amyloidosis: an under-recognized neuropathy and cardiomyopathy
Univ Toronto, Univ Hlth Network, Princess Margaret Canc Ctr, Dept Med Biophys, TMDT 4-305,101 Coll St, Toronto, ON M5G 1L7, Canada..
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology.
Prothena Biosci Inc, San Francisco, CA 94080 USA..
Univ Toronto, Univ Hlth Network, Princess Margaret Canc Ctr, Dept Med Biophys, TMDT 4-305,101 Coll St, Toronto, ON M5G 1L7, Canada..
2017 (English)In: Clinical Science, ISSN 0143-5221, E-ISSN 1470-8736, Vol. 131, no 5, 395-409 p.Article, review/survey (Refereed) Published
Abstract [en]

Transthyretin (TTR) amyloidosis (ATTR amyloidosis) is an underdiagnosed and important type of cardiomyopathy and/or polyneuropathy that requires increased awareness within the medical community. Raising awareness among clinicians about this type of neuropathy and lethal form of heart disease is critical for improving earlier diagnosis and the identification of patients for treatment. The following review summarizes current criteria used to diagnose both hereditary and wild-type ATTR (ATTRwt) amyloidosis, tools available to clinicians to improve diagnostic accuracy, available and newly developing therapeutics, as well as a brief biochemical and biophysical background of TTR amyloidogenesis.

Place, publisher, year, edition, pages
PORTLAND PRESS LTD , 2017. Vol. 131, no 5, 395-409 p.
National Category
Cardiac and Cardiovascular Systems
Identifiers
URN: urn:nbn:se:uu:diva-320086DOI: 10.1042/CS20160413ISI: 000394244500005PubMedID: 28213611OAI: oai:DiVA.org:uu-320086DiVA: diva2:1092577
Available from: 2017-05-03 Created: 2017-05-03 Last updated: 2017-05-03Bibliographically approved

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