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Environmental Health and Long Non-coding RNAs.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
2016 (English)In: Current environmental health reports, ISSN 2196-5412, Vol. 3, no 3, 178-87 p.Article in journal (Refereed) Published
Abstract [en]

An individual's risk of developing a common disease typically depends on an interaction of genetic and environmental factors. Epigenetic research is uncovering novel ways through which environmental factors such as diet, air pollution, and chemical exposure can affect our genes. DNA methylation and histone modifications are the most commonly studied epigenetic mechanisms. The role of long non-coding RNAs (lncRNAs) in epigenetic processes has been more recently highlighted. LncRNAs are defined as transcribed RNA molecules greater than 200 nucleotides in length with little or no protein-coding capability. While few functional lncRNAs have been well characterized to date, they have been demonstrated to control gene regulation at every level, including transcriptional gene silencing via regulation of the chromatin structure and DNA methylation. This review aims to provide a general overview of lncRNA function with a focus on their role as key regulators of health and disease and as biomarkers of environmental exposure.

Place, publisher, year, edition, pages
2016. Vol. 3, no 3, 178-87 p.
Keyword [en]
Chemicals, Disease, Epigenetics, LncRNA, Smoking, Toxicology
National Category
Environmental Health and Occupational Health Medical Genetics Pharmacology and Toxicology
Identifiers
URN: urn:nbn:se:uu:diva-321821DOI: 10.1007/s40572-016-0092-1PubMedID: 27234044OAI: oai:DiVA.org:uu-321821DiVA: diva2:1094922
Available from: 2017-05-11 Created: 2017-05-11 Last updated: 2017-05-11

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