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Intra-bone marrow injection of trace elements co-doped calcium phosphate microparticles for the treatment of osteoporotic rat
Zhejiang Univ, Zhejiang Calif Int Nanosyst Inst, Bionanomat & Regenerat Med Res Div, Yuhangtang Rd 866, Hangzhou 310058, Zhejiang, Peoples R China..
Zhejiang Univ, Affiliated Hosp 1, Dept Orthopaed Surg, Sch Med, Hangzhou 310003, Zhejiang, Peoples R China..
Zhejiang Univ, Zhejiang Calif Int Nanosyst Inst, Bionanomat & Regenerat Med Res Div, Yuhangtang Rd 866, Hangzhou 310058, Zhejiang, Peoples R China.;Zhejiang Prov Peoples Hosp, Clin Res Inst, Hangzhou 310014, Zhejiang, Peoples R China..
Zhejiang Univ, Zhejiang Calif Int Nanosyst Inst, Bionanomat & Regenerat Med Res Div, Yuhangtang Rd 866, Hangzhou 310058, Zhejiang, Peoples R China..
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2017 (English)In: Journal of Biomedical Materials Research. Part A, ISSN 1549-3296, E-ISSN 1552-4965, Vol. 105, no 5, 1422-1432 p.Article in journal (Refereed) Published
Abstract [en]

Osteoporotic femur fractures are the most common fragility fracture and account for approximately one million injuries per year. Local intervention by intra-marrow injection is potentially a good choice for preventing osteoporotic bone loss when the osteoporotic femoral fracture was treated. Previously, it was shown that trace element co-doped calcium phosphate (teCaP) implants could stimulate osteoporotic bone marrow mesenchymal stem cell activity in vitro and bone regeneration in femoral bone defects in osteoporotic animal models. They hypothesized that local intra-marrow injection of teCaP particles could improve bone function because the teCaP can sustain release of biologically essential inorganic minerals and improve bone remodeling in osteoporosis. The teCaP and CaP particles were synthesized in simulated body fluid with and without adding silicon, zinc and strontium ions. Female rats (8 months) were ovariectomized (OVX) or sham-operated, and then intervened in the femoral marrow space at 12 months old. Groups include: (1) saline water; (2) CaP particles; and (3) teCaP particles. After 2-3 months of intervention, the sham groups showed higher bone mineral density (MBD) in the femur, and teCaP group increased the BMD in the OVX groups. The compressive strength of the OVX-teCaP group was significantly higher than that in the OVX-CaP group. Significant differences between OVX-teCaP and OVX-CaP groups were found for bone mineral microarchitecture, bone mineral density, and trace mineral content, but not for feces composition. These results confirm the teCaP particles could suppress osteoporotic bone loss by local intramarrow injection. Therefore, this biomaterial could be used as a next-generation combination treatment for osteoporotic trauma and osteoporosis itself.

Place, publisher, year, edition, pages
2017. Vol. 105, no 5, 1422-1432 p.
Keyword [en]
antiosteoporosis, trace element, calcium phosphate, local intramarrow injection, osteoporotic fracture
National Category
Biomaterials Science Materials Engineering Biomedical Laboratory Science/Technology
Identifiers
URN: urn:nbn:se:uu:diva-321173DOI: 10.1002/jbm.a.36027ISI: 000398211300019PubMedID: 28233417OAI: oai:DiVA.org:uu-321173DiVA: diva2:1095279
Available from: 2017-05-12 Created: 2017-05-12 Last updated: 2017-05-12Bibliographically approved

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