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Delivery systems for antimicrobial peptides
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmacy.ORCID iD: 0000-0001-5626-3959
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmacy. Univ Copenhagen, Dept Pharm, DK-2100 Copenhagen, Denmark..
2017 (English)In: Advances in Colloid and Interface Science, ISSN 0001-8686, E-ISSN 1873-3727, Vol. 242, 17-34 p.Article in journal (Refereed) Published
Abstract [en]

Due to rapidly increasing resistance development against conventional antibiotics, finding novel approaches for the treatment of infections has emerged as a key health issue. Antimicrobial peptides (AMPs) have attracted interest in this context, and there is by now a considerable literature on the identification such peptides, as well as on their optimization to reach potent antimicrobial and anti-inflammatory effects at simultaneously low toxicity against human cells. In comparison, delivery systems for antimicrobial peptides have attracted considerably less interest. However, such delivery systems are likely to play a key role in the development of potent and safe AMP based therapeutics, e.g., through reducing chemical or biological degradation of AMPs either in the formulation or after administration, by reducing adverse side-effects, by controlling AMP release rate, by promoting biofilm penetration, or through achieving co-localization with intracellular pathogens. Here, an overview is provided of the current understanding of delivery systems for antimicrobial peptides, with special focus on AMP-carrier interactions, as well as consequences of these interactions for antimicrobial and related biological effects of AMP-containing formulations.

Place, publisher, year, edition, pages
ELSEVIER SCIENCE BV , 2017. Vol. 242, 17-34 p.
Keyword [en]
Antimicrobial peptide, Drug delivery, Infection
National Category
Pharmaceutical Sciences
Identifiers
URN: urn:nbn:se:uu:diva-322216DOI: 10.1016/j.cis.2017.01.005ISI: 000399519300002OAI: oai:DiVA.org:uu-322216DiVA: diva2:1096397
Funder
Swedish Research Council, 2012-1842EU, European Research Council, 604182
Available from: 2017-05-17 Created: 2017-05-17 Last updated: 2017-05-22Bibliographically approved

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CiteExportLink to record
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Citation style
  • apa
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  • nn-NB
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Output format
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