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Brief Report: Association Between Autism Spectrum Disorder, Gastrointestinal Problems and Perinatal Risk Factors Within Sibling Pairs.
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2017 (English)In: Journal of autism and developmental disorders, ISSN 0162-3257, E-ISSN 1573-3432Article in journal (Refereed) Epub ahead of print
Abstract [en]

Autism spectrum disorder (ASD) has been associated with gastrointestinal (GI) problems, but the nature of this association is unclear. Parents to siblings, concordant or discordant for ASD (N = 217), participated in a web survey covering mother's weight gain during pregnancy, maternal viral/bacterial infection and use of antibiotics, duration of breastfeeding, mode of delivery, birth weight and child GI problems. ASD was associated with GI problems and perinatal environmental risk, based on a summation of maternal infection and antibiotic use during pregnancy and/or the breastfeeding period. The association between GI problems and ASD remained within the sibling pairs (β = 1.23; p < .001) in the adjusted model. Our results indicate non-shared environmental effects on the ASD/GI association, but none of the factors examined explained the link.

Place, publisher, year, edition, pages
2017.
Keyword [en]
Autism spectrum disorder, Breastfeeding, Cesarean section, Gastrointestinal problems, Infections, Siblings
National Category
Psychiatry
Identifiers
URN: urn:nbn:se:uu:diva-322594DOI: 10.1007/s10803-017-3169-2PubMedID: 28536957OAI: oai:DiVA.org:uu-322594DiVA: diva2:1098849
Available from: 2017-05-26 Created: 2017-05-26 Last updated: 2017-05-26

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