uu.seUppsala University Publications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Ranolazine After Incomplete Percutaneous Coronary Revascularization in Patients With Versus Without Diabetes Mellitus: RIVER-PCI Trial
Duke Univ, Med Ctr, Div Cardiol, Dept Med, Durham, NC 27710 USA.;Duke Univ, Med Ctr, Duke Clin Res Inst, 2400 Pratt St, Durham, NC 27705 USA..
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, UCR-Uppsala Clinical Research Center. Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Cardiology.ORCID iD: 0000-0003-4413-9736
Columbia Univ, Div Cardiol, New York, NY USA.;Cardiovasc Res Fdn, New York, NY USA.;Shaare Zedek Med Ctr, Dept Cardiol, Jerusalem, Israel..
Duke Univ, Med Ctr, Duke Clin Res Inst, 2400 Pratt St, Durham, NC 27705 USA..
Show others and affiliations
2017 (English)In: Journal of the American College of Cardiology, ISSN 0735-1097, E-ISSN 1558-3597, Vol. 69, no 18, 2304-2313 p.Article in journal (Refereed) Published
Abstract [en]

BACKGROUND Chronic angina is more common in patients with diabetes mellitus (DM) with poor glucose control. Ranolazine both treats chronic angina and improves glucose control.

OBJECTIVES This study sought to examine ranolazine's antianginal effect in relation to glucose control.

METHODS The authors performed a secondary analysis of the RIVER-PCI (Ranolazine in Patients with Incomplete Revascularization after Percutaneous Coronary Intervention) trial, a clinical trial in which 2,604 patients with chronic angina and incomplete revascularization following percutaneous coronary intervention were randomized to ranolazine versus placebo. Mixed-effects models were used to compare the effects of ranolazine versus placebo on glycosylated hemoglobin (HbA(1c)) at 6- and 12-month follow-up. Interaction between baseline HbA(1c) and ranolazine's effect on Seattle Angina Questionnaire angina frequency at 6 and 12 months was tested.

RESULTS Overall, 961 patients (36.9%) had DM at baseline. Compared with placebo, ranolazine significantly decreased HbA(1c) by 0.42 +/- 0.08% (adjusted mean difference +/- SE) and 0.44 +/- 0.08% from baseline to 6 and 12 months, respectively, in DM patients, and by 0.19 +/- 0.02% and 0.20 +/- 0.02% at 6 and 12 months, respectively, in non-DM patients. Compared with placebo, ranolazine significantly reduced Seattle Angina Questionnaire angina frequency at 6 months among DM patients but not at 12 months. The reductions in angina frequency were numerically greater among patients with baseline HbA(1c) >= 7.5% than those with HbA(1c) <7.5% (interaction p = 0.07).

CONCLUSIONS In patients with DM and chronic angina with incomplete revascularization after percutaneous coronary intervention, ranolazine's effect on glucose control and angina at 6 months was proportionate to baseline HbA(1c), but the effect on angina dissipated by 12 months.

Place, publisher, year, edition, pages
2017. Vol. 69, no 18, 2304-2313 p.
Keyword [en]
chronic angina, coronary artery disease, glucose control, hemoglobin A(1c)
National Category
Cardiac and Cardiovascular Systems
Identifiers
URN: urn:nbn:se:uu:diva-322519DOI: 10.1016/j.jacc.2017.02.056ISI: 000400247500009PubMedID: 28473136OAI: oai:DiVA.org:uu-322519DiVA: diva2:1098973
Funder
NIH (National Institute of Health), 5T32HL069749Eli LillyAstraZeneca
Available from: 2017-05-29 Created: 2017-05-29 Last updated: 2017-05-29Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
James, Stefan K.
By organisation
UCR-Uppsala Clinical Research CenterCardiology
In the same journal
Journal of the American College of Cardiology
Cardiac and Cardiovascular Systems

Search outside of DiVA

GoogleGoogle Scholar

Altmetric score

Total: 24 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf