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Incidence and prognostic significance of isolated trisomies in adult acute myeloid leukemia: A population-based study from the Swedish AML registry
Skane Univ Hosp, Dept Hematol Oncol & Radiat Phys, Lund, Sweden.;Lund Univ, Stem Cell Ctr, Lund, Sweden..
Skane Univ Hosp, Epidemiol & Registry Ctr South Sweden, Lund, Sweden.;Lund Univ, Dept Translat Med, Med Radiol, Lund, Sweden..
Skane Univ Hosp, Dept Hematol Oncol & Radiat Phys, Lund, Sweden.;Lund Univ, Stem Cell Ctr, Lund, Sweden..
Linkoping Univ Hosp, Dept Hematol, Linkoping, Sweden..
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2017 (English)In: European Journal of Haematology, ISSN 0902-4441, E-ISSN 1600-0609, Vol. 98, no 5, 493-500 p.Article in journal (Refereed) Published
Abstract [en]

Objectives and MethodsTo ascertain the incidence/clinical implications of isolated autosomal trisomies in adult acute myeloid leukemia (AML), all such cases were retrieved from the Swedish AML Registry. ResultsOf the 3179 cytogenetically informative AMLs diagnosed January 1997-May 2015, 246 (7.7%) had isolated trisomies. The frequency increased by age (2.4% at age 18-60years vs. 23% at >60years; P<.0001); the median age was 69years. The five most common were +8 (4.0%), +13 (0.9%), +11 (0.8%), +21 (0.7%), and +4 (0.5%). Age and gender, types of AML and treatment, and complete remission and early death rates did not differ between the single trisomy and the intermediate risk (IR) groups or among cases with isolated gains of chromosomes 4, 8, 11, 13, or 21. The overall survival (OS) was similar in the single trisomy (median 1.6years) and IR groups (1.7years; P=.251). The OS differed among the most frequent isolated trisomies; the median OS was 2.5years for +4, 1.9years for +21, 1.5years for +8, 1.1years for +11, and 0.8years for +13 (P=.013). ConclusionAML with single trisomies, with the exception of +13, should be grouped as IR.

Place, publisher, year, edition, pages
WILEY , 2017. Vol. 98, no 5, 493-500 p.
Keyword [en]
acute myeloid leukemia, autosomal trisomy, clinical characteristics, survival
National Category
Hematology
Identifiers
URN: urn:nbn:se:uu:diva-322686DOI: 10.1111/ejh.12861ISI: 000399882100009PubMedID: 28152233OAI: oai:DiVA.org:uu-322686DiVA: diva2:1099138
Available from: 2017-05-29 Created: 2017-05-29 Last updated: 2017-05-29Bibliographically approved

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