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Spinal nerve lesion alters blood-spinal cord barrier function and activates astrocytes in the rat
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Anaesthesiology and Intensive Care.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Anaesthesiology and Intensive Care.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Anaesthesiology and Intensive Care.
2006 (English)In: Pain, ISSN 0304-3959, E-ISSN 1872-6623, Vol. 124, no 1-2, 211-221 p.Article in journal (Refereed) Published
Abstract [en]

Alterations in the spinal cord microenvironment in a neuropathic pain model in rats comprising right L-4 spinal nerve lesion were examined following 1, 2, 4 and 10 weeks using albumin and glial fibrillary acidic protein (GFAP) immunoreactivity. Rats subjected to nerve lesion showed pronounced activation of GFAP indicating astrocyte activation, and exhibited marked leakage of albumin, suggesting defects of the blood-spinal cord barrier (BSCB) function in the corresponding spinal cord segment. The intensities of these changes were most prominent in the gray matter of the lesioned side compared to them contralateral cord in both the dorsal and ventral horns. The most marked changes in albumin and GFAP inummoreaction were seen after 2 weeks and persisted with mild intensities even after 10 weeks. Distortion of nerve cells, loss of neurons and general sponginess were evident in the gray matter of the spinal cord corresponding to the lesion side. These nerve cell and glial cell changes are mainly evident in the areas showing leakage of endogenous albumin in the spinal cord. These novel observations indicate that chronic nerve lesion has the capacity to induce a selective increase in local BSCB permeability that could be instrumental in nerve cell and glial cell activation. These findings may be relevant to our current understanding on the pathophysiology of neuropathic pain.

Place, publisher, year, edition, pages
2006. Vol. 124, no 1-2, 211-221 p.
Keyword [en]
nerve lesion, neuropathic pain, blood-spinal cord barrier permeability, astrocytes, glial fibrillary acidic protein immunoreactivity, albumin extravasation, spinal cord microenvironment, neuronal damage
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-82044DOI: 10.1016/j.pain.2006.05.020ISI: 000240581700030PubMedID: 16806707OAI: oai:DiVA.org:uu-82044DiVA: diva2:109959
Available from: 2006-09-12 Created: 2006-09-12 Last updated: 2011-06-15Bibliographically approved

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Gordh, TorstenSharma, Hari Shanker

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