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Gastric-type H+,K+-ATPase in mouse vestibular end organs
Univ Hosp, Dept Otolaryngol, Hiroshima, Japan..
Univ Tokyo Hosp, Tokyo, Japan..
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Otolaryngology and Head and Neck Surgery.
2017 (English)In: Acta Oto-Laryngologica, ISSN 0001-6489, E-ISSN 1651-2251, Vol. 137, no 5, 455-459 p.Article in journal (Refereed) Published
Abstract [en]

Conclusion: Gastric type H+,K+-ATPase in the vestibular end organs may be of importance for K+ circulation and may also be related to pH regulation in vestibular end organs and endolymphatic sac. Objective: To analyze the expression of gastric-type H+,K+-ATPase in normal mouse vestibular end organs. Methods: 8 weeks old CBA/J mice were used in this study. The presence of gastric-type H+,K+-ATPase alpha and beta in the vestibular end organs, viz. utricle, saccule, ampulla, vestibular ganglion, and endolymphatic sac, was investigated using immunohistochemistry. Results: In the vestibular end organs, H+,K+-ATPase alpha and beta were almost identical. H+,K+-ATPase was expressed in sensory cells, the basolateral surface of dark cells, fibrocytes, in vestibular ganglion cells, and in the upper region of the endolymphatic sac epithelial cells.

Place, publisher, year, edition, pages
Taylor & Francis, 2017. Vol. 137, no 5, 455-459 p.
Keyword [en]
Hydrogen, potassium-adenosine triphosphatase, vestibular end organ, immunohistochemistry
National Category
Otorhinolaryngology
Identifiers
URN: urn:nbn:se:uu:diva-322674DOI: 10.1080/00016489.2016.1245865ISI: 000400167100001PubMedID: 27768854OAI: oai:DiVA.org:uu-322674DiVA: diva2:1103294
Available from: 2017-05-30 Created: 2017-05-30 Last updated: 2017-05-30Bibliographically approved

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CiteExportLink to record
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