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How do individuals cope with stress?: Behavioural, physiological and neuronal differences between proactive and reactive coping styles in fish
Uni Res AS, Uni Environm, NO-5020 Bergen, Norway.;Univ Oslo, Dept Biosci, NO-0316 Oslo, Norway..
Radboud Univ Nijmegen, Inst Water & Wetland Res, Dept Anim Ecol & Physiol, NL-6525 AJ Nijmegen, Netherlands..
Tech Univ Denmark, Natl Inst Aquat Resources, DK-9850 Hirtshals, Denmark..
Radboud Univ Nijmegen, Inst Water & Wetland Res, Dept Anim Ecol & Physiol, NL-6525 AJ Nijmegen, Netherlands..
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2017 (English)In: Journal of Experimental Biology, ISSN 0022-0949, E-ISSN 1477-9145, Vol. 220, no 8, p. 1524-1532Article in journal (Refereed) Published
Abstract [en]

Despite the use of fish models to study human mental disorders and dysfunctions, knowledge of regional telencephalic responses in non-mammalian vertebrates expressing alternative stress coping styles is poor. As perception of salient stimuli associated with stress coping in mammals is mainly under forebrain limbic control, we tested region-specific forebrain neural (i.e. mRNA abundance and monoamine neurochemistry) and endocrine responses under basal and acute stress conditions for previously characterised proactive and reactive Atlantic salmon. Reactive fish showed a higher degree of the neurogenesis marker proliferating cell nuclear antigen (pcna) and dopamine activity under basal conditions in the proposed hippocampus homologue (Dl) and higher post-stress plasma cortisol levels. Proactive fish displayed higher post-stress serotonergic signalling (i.e. higher serotonergic activity and expression of the 5-HT1A receptor) in the proposed amygdala homologue (Dm), increased expression of the neuroplasticity marker brain-derived neurotropic factor (bdnf) in both Dl and the lateral septum homologue (Vv), as well as increased expression of the corticotropin releasing factor 1 (crf(1)) receptor in the Dl, in line with active coping neuro-profiles reported in the mammalian literature. We present novel evidence of proposed functional equivalences in the fish forebrain with mammalian limbic structures.

Place, publisher, year, edition, pages
2017. Vol. 220, no 8, p. 1524-1532
Keywords [en]
Atlantic salmon, Limbic areas, Neural plasticity, BDNF, Serotonin
National Category
Physiology
Identifiers
URN: urn:nbn:se:uu:diva-322814DOI: 10.1242/jeb.153213ISI: 000399670800023PubMedID: 28167808OAI: oai:DiVA.org:uu-322814DiVA, id: diva2:1103627
Funder
EU, FP7, Seventh Framework ProgrammeAvailable from: 2017-05-30 Created: 2017-05-30 Last updated: 2018-01-13Bibliographically approved

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Thörnqvist, Per-OveWinberg, Svante

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