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Changes in inflammatory molecules in patients with allergic asthma: relations to anti-inflammatory treatment and asthma control
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Biosciences.
2017 (English)Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
Abstract [en]

Introduction: Asthma is characterized by chronic inflammation of the airways. Allergic asthma is mediated by TH2-cells and characterized by the presence of  serum IgE antibodies. Asthma is a heterogenous disease with different phenotypes emerging. Non-allergic asthma lacks obvious TH2-cell involvement. Aim: The aim of this post-hoc study was to investigate if optimization of anti-inflammatory treatment affected the biomarkers IgE, FeNO, ECP, CRP and HNL, and cytokine concentrations and if the changes could be related to each other and asthma control. Materials and methods: A total of 159 asthmatics (age 18-64 years) were included, all participants had verified allergen sensitization. Anti-inflammatory treatment consisted of ICS and LTRA. Concentrations of biomarkers and cytokines were measured at baseline and after one year. Asthma control was measured at six occasions. Results: The main finding of this study was that changes in MMP-10 concentration correlated with changes in FeNO, total-IgE and CRP (p=0.0002, p=0.0068, p=0.0016). Decreased concentrations of MMP-10 was associated with improved asthma control ( p= 0.0281). Reduction of ECP and total-IgE (p= 0.0107, p= 0.0191) were also associated with improved asthma control. Conclusion: The results suggests that MMP-10 was associated with both TH2 and non-TH2-mediated asthma, which could explain why MMP-10 was the only cytokine associated with improved asthma control. The reults also suggests that improved asthma control was obtained by decreasing concentrations of systemic biomarkers rather than the local biomarker, FeNO. 

Place, publisher, year, edition, pages
2017.
Keyword [en]
allergic asthma, Exhaled nitric oxide
National Category
Pharmaceutical Sciences
Identifiers
URN: urn:nbn:se:uu:diva-323333OAI: oai:DiVA.org:uu-323333DiVA: diva2:1105828
Subject / course
Pharmacotherapy
Educational program
Master of Science Programme in Pharmacy
Supervisors
Examiners
Available from: 2017-06-07 Created: 2017-06-05 Last updated: 2017-06-07Bibliographically approved

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