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Maximization of Selectivity in Reversed-Phase Liquid Chromatographic Method Development Strategies
Hichrom Ltd, Reading, Berks, England.;Univ Strathclyde, Glasgow, Lanark, Scotland.;Open Univ, Milton Keynes, Bucks, England..
Hichrom Ltd, Reading, Berks, England..
Hichrom Ltd, Reading, Berks, England..
Hichrom Ltd, Reading, Berks, England..
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2017 (English)In: LC GC North America, ISSN 1527-5949, E-ISSN 1939-1889, Vol. 35, no 4, 258-272 p.Article in journal (Refereed) Published
Abstract [en]

The selectivity of different combinations.of organic modifiers, pH, and types of reversed-phase liquid chromatography (LC) materials has been characterized using Tanaka column characterization, linear solvent energy relationships (LSER), and selectivity correlations. The three characterization techniques highlighted the potential complementary selectivity of these phases and conditions as well as the type and dominancy of some of the retention mechanisms involved. Subsequently, selectivity differences were proven to be valid in the practical separation of acids, bases, and neutral analytes. This paper aims to help chromatographers to produce highly efficient method development strategies for reversed phase LC separations in a relatively short time frame.

Place, publisher, year, edition, pages
2017. Vol. 35, no 4, 258-272 p.
National Category
Analytical Chemistry
Identifiers
URN: urn:nbn:se:uu:diva-322846ISI: 000400205400006OAI: oai:DiVA.org:uu-322846DiVA: diva2:1106688
Note

Title in Web of Science: Maximization of Selectivity in Reversed Phase Liquid Chromatographic Method Development Strategies

Available from: 2017-06-08 Created: 2017-06-08 Last updated: 2017-06-08Bibliographically approved

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