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A European Respiratory Society technical standard: exhaled biomarkers in lung disease
Natl Koranyi Inst Pulmonol, Dept Pulmonol, Piheno Ut 1, Budapest, Hungary..
Imperial Coll London, Royal Brompton Hosp, Natl Heart & Lung Inst, London, England..
Nimits Hosp, Pulm Dept, Athens, Greece..
Univ Amsterdam, Acad Med Ctr, Dept Resp Med, Amsterdam, Netherlands..
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2017 (English)In: European Respiratory Journal, ISSN 0903-1936, E-ISSN 1399-3003, Vol. 49, no 4, 1600965Article in journal (Refereed) Published
Abstract [en]

Breath tests cover the fraction of nitric oxide in expired gas (FeNO), volatile organic compounds (VOCs), variables in exhaled breath condensate (EBC) and other measurements. For EBC and for FeNO, official recommendations for standardised procedures are more than 10 years old and there is none for exhaled VOCs and particles. The aim of this document is to provide technical standards and recommendations for sample collection and analytic approaches and to highlight future research priorities in the field. For EBC and FeNO, new developments and advances in technology have been evaluated in the current document. This report is not intended to provide clinical guidance on disease diagnosis and management.

Clinicians and researchers with expertise in exhaled biomarkers were invited to participate. Published studies regarding methodology of breath tests were selected, discussed and evaluated in a consensus-based manner by the Task Force members.

Recommendations for standardisation of sampling, analysing and reporting of data and suggestions for research to cover gaps in the evidence have been created and summarised.

Application of breath biomarker measurement in a standardised manner will provide comparable results, thereby facilitating the potential use of these biomarkers in clinical practice.

Place, publisher, year, edition, pages
2017. Vol. 49, no 4, 1600965
National Category
Respiratory Medicine and Allergy
Identifiers
URN: urn:nbn:se:uu:diva-322843DOI: 10.1183/13993003.00965-2016ISI: 000400342500003OAI: oai:DiVA.org:uu-322843DiVA: diva2:1106694
Available from: 2017-06-08 Created: 2017-06-08 Last updated: 2017-06-08Bibliographically approved

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