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Does human relaxin-2 affect peripheral blood mononuclear cells to increase inflammatory mediators in pathologic bone loss?
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Public Health and Caring Sciences, Family Medicine and Clinical Epidemiology.
2005 (English)In: Annals of the New York Academy of Sciences, ISSN 0077-8923, E-ISSN 1749-6632, Vol. 1041, 317-9 p.Article in journal (Refereed) Published
Abstract [en]

This study was designed to test the hypothesis that relaxin stimulates bone resorption by regulating the production of several mediators that stimulate osteoclast formation. The levels of mediators were measured in response to differing relaxin concentrations in supernatants from peripheral blood mononuclear cells (PBMCs), MCF-7 breast cancer cells, and normal human osteoblasts. Although all cell types expressed mRNA for the relaxin receptor (LGR7), only PBMCs responded to relaxin at physiologic levels by increasing tumor necrosis factor-α and interleukin-1β secretion. The findings indicate that PBMCs should be studied in relation to the effect of relaxin on inflammation and bone destruction caused by osteoclasts.

Place, publisher, year, edition, pages
2005. Vol. 1041, 317-9 p.
Keyword [en]
Bone Resorption/*metabolism/*pathology, Cells; Cultured, Humans, Inflammation Mediators/metabolism, Interleukin-1/*secretion, Monocytes/*drug effects/metabolism, Relaxin/*pharmacology, Tumor Necrosis Factor-alpha/*secretion
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-83141DOI: 10.1196/annals.1282.050PubMedID: 15956727OAI: oai:DiVA.org:uu-83141DiVA: diva2:111048
Available from: 2006-10-19 Created: 2006-10-19 Last updated: 2011-08-15Bibliographically approved

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