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Dynamic Coordination Chemistry Enables Free Directional Printing of Biopolymer Hydrogel
Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Chemistry - Ångström, Polymer Chemistry.
Uppsala University, Disciplinary Domain of Science and Technology, Physics, Department of Physics and Astronomy, Materials Physics.
Institute of Materials Science and Technology, Technische Universität Wien.
Institute of Materials Science and Technology, Technische Universität Wien.
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2017 (English)In: Chemistry of Materials, Vol. 29, 5816-5823 p.Article in journal (Refereed) Published
Abstract [en]

Three-dimensional (3D) printing is a promising technology to develop customized biomaterials in regenerative medicine. However, for the majority of printable biomaterials (bioinks) there is always a compromise between excellent printability of fluids and good mechanical properties of solids. 3D printing of soft materials based on the transition from a fluid to gel state is challenging because of the difficulties to control such transition as well as to maintain uniform conditions three-dimensionally. To solve these challenges, a facile chemical strategy for the development of a novel hydrogel bioink with shear-thinning and self-healing properties based on dynamic metal-ligand coordination bonds is presented. The non-covalent cross-linking allows easy extrusion of the bioink from a reservoir without changing of its bulk mechanical properties. The soft hydrogel can avoid deformation and collapse using omnidirectional embedding of the printable hydrogel into a support gel bath sharing the same cross-linking chemistry. After combination with photo-initiated covalent cross-linking, it enables manufacturing of hydrogel structures with complex shapes and precise location of chemically attached ligands. Living cells can be entrapped in the new printable hydrogel and survive the following in situ photocross-linking. The presented printable hydrogel mate-rial expands the existing tool-box of bioinks for generation of in vitro 3D tissue-like structures and direct in vivo 3D printing.

Place, publisher, year, edition, pages
American Chemical Society (ACS), 2017. Vol. 29, 5816-5823 p.
National Category
Polymer Chemistry
Identifiers
URN: urn:nbn:se:uu:diva-324796DOI: 10.1021/acs.chemmater.7b00128OAI: oai:DiVA.org:uu-324796DiVA: diva2:1111592
Available from: 2017-06-19 Created: 2017-06-19 Last updated: 2017-08-04

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Shi, LiyangCarstensen, HaukeLi, HaoHilborn, JönsOssipov, Dmitri
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