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Effects of amoxicillin on the expression of cytokines during experimental acute otitis media caused by non-typeable Haemophilus influenzae
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
2001 (English)In: Journal of Antimicrobial Chemotherapy, ISSN 0305-7453, Vol. 48, no 3, 397-402 p.Article in journal (Refereed) Published
Abstract [en]

Antibiotics are frequently prescribed when a diagnosis of acute otitis media (AOM) is made in childhood, but the effects of antibiotics on host-parasite interactions in the middle ear are not well defined. A rat model and PCR techniques were used to explore host responses during amoxicillin treatment of AOM caused by non-typeable Haemophilus influenzae (NTHi). The 5 day course of amoxicillin initiated at the otomicroscopic peak of the infection eradicated the bacteria and induced significant changes in the expression of cytokines. Interleukin (IL)-6, tumour necrosis factor-alpha and IL-10 were upregulated by the treatment, and the downregulation was slower than during the natural course. Amoxicillin inhibited the upregulation of transforming growth factor-beta, whereas IL-1alpha expression remained unaffected by the treatment. By comparing inflammatory host responses during treated and untreated NTHi AOM, new targets for modification of the course, or more specified and individualized treatments, may evolve.

Place, publisher, year, edition, pages
2001. Vol. 48, no 3, 397-402 p.
Keyword [en]
Acute Disease, Amoxicillin/*pharmacology, Animals, Cytokines/drug effects/genetics/*metabolism, Disease Models; Animal, Male, Otitis/*metabolism, Penicillins/*pharmacology, RNA; Messenger/drug effects/metabolism, Rats, Rats; Sprague-Dawley, Research Support; Non-U.S. Gov't
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Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-83404PubMedID: 11533005OAI: oai:DiVA.org:uu-83404DiVA: diva2:111312
Available from: 2006-11-02 Created: 2006-11-02Bibliographically approved

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Melhus, Åsa

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