uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Immunization and protection in pneumococcal otitis media studied in a rat model
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
Show others and affiliations
1999 (English)In: Microbial Drug Resistance, ISSN 1076-6294, Vol. 5, no 1, 73-82 p.Article in journal (Refereed) Published
Abstract [en]

The recent and growing problem of bacterial resistance to common antibiotics has generated great interest in different methods for prevention of infections. The treatment of the pathogens causing upper airway infections and especially acute otitis media (AOM) is especially interesting in this context because these infections are a common cause of prescription of antibiotics all over the world. Both in AOM and recurrent AOM, Streptococcus pneumoniae, the most frequently occurring bacterium is isolated in 30-50% of all AOM attacks. In the last decade, multiresistant S. pneumoniae have emerged as a major problem. Thus, it is important to explore possibilities that immunization may protect against pneumococcal OM. In a well-defined animal model using Sprague-Dawley rats, we have investigated the effects of different routes of immunization with different antigens and whole cells. Together with otomicroscopical evaluation of middle ear (ME) status, samples for bacterial cultivation as well as for studies of histopathological changes have been collected. Antibody titers have been followed during and after pneumococcal AOM by an enzyme-linked immunosorbent assay (ELISA) method.

Place, publisher, year, edition, pages
1999. Vol. 5, no 1, 73-82 p.
Keyword [en]
Animals, Antibodies; Bacterial/biosynthesis, Antigens; Bacterial, Bacterial Vaccines, Disease Models; Animal, Immunization, Otitis Media/*immunology/*prevention & control, Pneumococcal Infections/*immunology/*prevention & control, Rats, Rats; Sprague-Dawley, Streptococcus pneumoniae/immunology
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-83415PubMedID: 10332724OAI: oai:DiVA.org:uu-83415DiVA: diva2:111323
Available from: 2006-11-02 Created: 2006-11-02Bibliographically approved

Open Access in DiVA

No full text

Other links


Search in DiVA

By author/editor
Melhus, Åsa
By organisation
Department of Medical Sciences
In the same journal
Microbial Drug Resistance
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar

Altmetric score

Total: 118 hits
ReferencesLink to record
Permanent link

Direct link