uu.seUppsala University Publications
Change search
ReferencesLink to record
Permanent link

Direct link
Effect of Haemophilus influenzae type b conjugate vaccine in combination with peroral immunization with Escherichia coli on experimental otitis media
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
1996 (English)In: International Journal of Pediatric Otorhinolaryngology, ISSN 0165-5876, Vol. 36, no 1, 1-12 p.Article in journal (Refereed) Published
Abstract [en]

The protective ability of a conjugated Haemophilus influenzae type b vaccine, ACT-HIB, used singly or in combination with orally administered Escherichia coli, was investigated in a rat model for acute otitis media. The humoral response to ACT-HIB was also analyzed. The study demonstrated that ACT-HIB vaccination resulted in a prompt antibody response, and that ACT-HIB was efficient in preventing middle ear infections caused by Haemophilus influenzae type b. The efficiency increased if the vaccine was combined with Escherichia coli. The results suggest that Escherichia coli could possibly be useful in the future as a vaccine vehicle, and since Haemophilus influenzae acute mastoiditis seems to be almost exclusively due to serotype b, the incidence of this infection may be reduced with the conjugated Haemophilus influenzae type b vaccines.

Place, publisher, year, edition, pages
1996. Vol. 36, no 1, 1-12 p.
Keyword [en]
Acute Disease, Administration; Oral, Animals, Escherichia coli/pathogenicity, Escherichia coli Infections/*prevention & control, Haemophilus Infections/*prevention & control, Haemophilus Vaccines/*administration & dosage/*therapeutic use, Haemophilus influenzae/pathogenicity, Male, Otitis Media/etiology/*immunology/prevention & control, Rats, Rats; Sprague-Dawley, Research Support; Non-U.S. Gov't, Vaccination
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-83428DOI: 10.1016/0165-5876(95)01319-9PubMedID: 8803686OAI: oai:DiVA.org:uu-83428DiVA: diva2:111336
Available from: 2006-11-02 Created: 2006-11-02Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMedhttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Retrieve&list_uids=8803686&dopt=Citation

Search in DiVA

By author/editor
Melhus, Åsa
By organisation
Department of Medical Sciences
In the same journal
International Journal of Pediatric Otorhinolaryngology
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 129 hits
ReferencesLink to record
Permanent link

Direct link