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Nontypeable and encapsulated Haemophilus influenzae yield different clinical courses of experimental otitis media
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences.
1994 (English)In: Acta Oto-Laryngologica, ISSN 0001-6489, Vol. 114, no 3, 289-294 p.Article in journal (Refereed) Published
Abstract [en]

Middle ears of male Sprague-Dawley rats were injected with suspensions of thirteen Haemophilus influenzae strains of different sero- and biotypes and at various concentrations. Systemic and local changes were monitored by clinical observations, otomicroscopy, and analysis of bacterial samples from blood and middle ears. Two patterns of response were recognized, a nontypeable and an encapsulated pattern. The nontypeable H. influenzae middle ear infection required a high bacterial dose and was well past its peak 8 days after challenge, when the encapsulated H. influenzae otitis media was still purulent. The most severe infections were caused by H. influenzae type b strains. The overall mortality rate was zero and the animals recovered without permanent deterioration or otomicroscopically discernable changes. The results of this study show the rat to be a suitable animal model for the study of H. influenzae otitis media.

Place, publisher, year, edition, pages
1994. Vol. 114, no 3, 289-294 p.
Keyword [en]
Acute Disease, Animals, Bacterial Capsules, Bacterial Typing Techniques, Disease Models; Animal, Haemophilus Infections/*microbiology/pathology, Haemophilus influenzae/isolation & purification, Male, Otitis Media/*microbiology/pathology, Rats, Rats; Sprague-Dawley
National Category
Medical and Health Sciences
URN: urn:nbn:se:uu:diva-83434PubMedID: 8073862OAI: oai:DiVA.org:uu-83434DiVA: diva2:111342
Available from: 2006-11-02 Created: 2006-11-02Bibliographically approved

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