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Recent Advances in Human Genetics and Epigenetics of Adiposity: Pathway to Precision Medicine?
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Sciences, Molecular epidemiology. Uppsala University, Science for Life Laboratory, SciLifeLab.ORCID iD: 0000-0003-2071-5866
Framingham Heart Dis Epidemiol Study, Framingham, MA USA.;NHLBI, Populat Sci Branch, NIH, Bldg 10, Bethesda, MD 20892 USA.;Boston Childrens Hosp, Dept Cardiol, Boston, MA USA..
Univ Michigan, Dept Internal Med, Div Gastroenterol, Ann Arbor, MI 48109 USA.;Univ Michigan, Dept Computat Med & Bioinformat, Ann Arbor, MI 48109 USA..
2017 (English)In: Gastroenterology, ISSN 0016-5085, E-ISSN 1528-0012, Vol. 152, no 7, p. 1695-1706Article in journal (Refereed) Published
Abstract [en]

Obesity is a heritable trait that contributes to substantial global morbidity and mortality. Here, we summarize findings from the past decade of genetic and epigenetic research focused on unravelling the underpinnings of adiposity. More than 140 genetic regions now are known to influence adiposity traits. The genetics of general adiposity, as measured by body mass index, and that of abdominal obesity, as measured by waist-to-hip ratio, have distinct biological backgrounds. Gene expression associated with general adiposity is enriched in the nervous system. In contrast, genes associated with abdominal adiposity function in adipose tissue. Recent population-based epigenetic analyses have highlighted additional distinct loci. We discuss how associated genetic variants can lead to understanding causal mechanisms, and to disentangling reverse causation in epigenetic analyses. Discoveries emerging from population genomics are identifying new disease markers and potential novel drug targets to better define and combat obesity and related diseases.

Place, publisher, year, edition, pages
W B SAUNDERS CO-ELSEVIER INC , 2017. Vol. 152, no 7, p. 1695-1706
Keywords [en]
Genetics, Epigenetics, Obesity, Adiposity
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:uu:diva-325346DOI: 10.1053/j.gastro.2017.01.054ISI: 000401812000007PubMedID: 28214526OAI: oai:DiVA.org:uu-325346DiVA, id: diva2:1114189
Funder
Swedish Research Council, 2015-03477Swedish Heart Lung Foundation, 20150429Swedish Research Council Formas, 221-2013-1673Göran Gustafsson Foundation for Research in Natural Sciences and MedicineAvailable from: 2017-06-22 Created: 2017-06-22 Last updated: 2017-06-22Bibliographically approved

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