Evidence for an immune function of lepidopteran silk proteins
2007 (English)In: Biochemical and Biophysical Research Communications - BBRC, ISSN 0006-291X, E-ISSN 1090-2104, Vol. 352, no 2, 317-322 p.Article in journal (Refereed) Published
Hemolymph coagulation stops bleeding and protects against infection. Clotting factors include both proteins that are conserved during evolution as well as more divergent proteins in different species. Here we show that several silk proteins also appear in the clot of the greater wax moth Galleria mellonella. RT-PCR analysis reveals that silk proteins are expressed in immune tissues and induced upon wounding in both Galleria and Ephestia kuehniella, a second pyralid moth. Our results support the idea that silk proteins were co-opted for immunity and coagulation during evolution.
Place, publisher, year, edition, pages
2007. Vol. 352, no 2, 317-322 p.
innate immunity, coagulation, silk, molecular evolution, Galleria, Ephestia, Drosophila, bleeding
IdentifiersURN: urn:nbn:se:uu:diva-83558DOI: 10.1016/j.bbrc.2006.11.022ISI: 000243196300007PubMedID: 17126296OAI: oai:DiVA.org:uu-83558DiVA: diva2:111466