uu.seUppsala University Publications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
U-CAN: a prospective longitudinal collection of biomaterials and clinical information from adult cancer patients in Sweden.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Experimental and Clinical Oncology.ORCID iD: 0000-0002-5440-791X
Umeå Univ, Dept Radiat Sci, Umeå.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Experimental and Clinical Oncology.ORCID iD: 0000-0002-0594-724x
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Clinical and experimental pathology.
Show others and affiliations
2018 (English)In: Acta Oncologica, ISSN 0284-186X, E-ISSN 1651-226X, Vol. 57, no 2, p. 187-194Article in journal (Refereed) Published
Abstract [en]

Background: Progress in cancer biomarker discovery is dependent on access to high-quality biological materials and high-resolution clinical data from the same cases. To overcome current limitations, a systematic prospective longitudinal sampling of multidisciplinary clinical data, blood and tissue from cancer patients was therefore initiated in 2010 by Uppsala and Umeå Universities and involving their corresponding University Hospitals, which are referral centers for one third of the Swedish population.

Material and Methods: Patients with cancer of selected types who are treated at one of the participating hospitals are eligible for inclusion. The healthcare-integrated sampling scheme encompasses clinical data, questionnaires, blood, fresh frozen and formalin-fixed paraffin-embedded tissue specimens, diagnostic slides and radiology bioimaging data.

Results: In this ongoing effort, 12,265 patients with brain tumors, breast cancers, colorectal cancers, gynecological cancers, hematological malignancies, lung cancers, neuroendocrine tumors or prostate cancers have been included until the end of 2016. From the 6914 patients included during the first five years, 98% were sampled for blood at diagnosis, 83% had paraffin-embedded and 58% had fresh frozen tissues collected. For Uppsala County, 55% of all cancer patients were included in the cohort.

Conclusions: Close collaboration between participating hospitals and universities enabled prospective, longitudinal biobanking of blood and tissues and collection of multidisciplinary clinical data from cancer patients in the U-CAN cohort. Here, we summarize the first five years of operations, present U-CAN as a highly valuable cohort that will contribute to enhanced cancer research and describe the procedures to access samples and data.

Place, publisher, year, edition, pages
2018. Vol. 57, no 2, p. 187-194
National Category
Cancer and Oncology Urology and Nephrology
Identifiers
URN: urn:nbn:se:uu:diva-325565DOI: 10.1080/0284186X.2017.1337926ISI: 000423473200003PubMedID: 28631533OAI: oai:DiVA.org:uu-325565DiVA, id: diva2:1115180
Funder
Swedish Cancer Society
Available from: 2017-06-26 Created: 2017-06-26 Last updated: 2018-03-09Bibliographically approved

Open Access in DiVA

fulltext(1301 kB)6 downloads
File information
File name FULLTEXT01.pdfFile size 1301 kBChecksum SHA-512
a8a04a498f67476cd53439f9326289d9f82cc7a0dbc95a41f76762583d85be9cd7fb9029c7582d03b7640f7db7545dcdfcec6fc03929f1dc97575b92e717c931
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Authority records BETA

Glimelius, BengtEnblad, GunillaAlafuzoff, IrinaBeskow, Anna H.Bill-Axelson, AnnaBirgisson, HelgiEdqvist, Per-Henrik DHansson, TonyHellman, PerHenriksson, KerstinHesselager, GöranHäggman, MichaelHöglund, MartinLarsson, ChatarinaLindman, HenrikMindus, StephanieNygren, PeterPonten, FredrikRosenquist, RichardStålberg, KarinStålberg, PeterSundström, ChristerWestermark, BengtClaesson-Welsh, LenaSjöblom, Tobias

Search in DiVA

By author/editor
Glimelius, BengtEnblad, GunillaAlafuzoff, IrinaBeskow, Anna H.Ahlström, HåkanBill-Axelson, AnnaBirgisson, HelgiEdqvist, Per-Henrik DHansson, TonyHelleday, ThomasHellman, PerHenriksson, KerstinHesselager, GöranHäggman, MichaelHöglund, MartinLarsson, ChatarinaLindman, HenrikMindus, StephanieNygren, PeterPonten, FredrikRosenquist, RichardStålberg, KarinStålberg, PeterSundström, ChristerWestermark, BengtClaesson-Welsh, LenaSjöblom, Tobias
By organisation
Experimental and Clinical OncologyClinical and experimental pathologyUCR-Uppsala Clinical Research CenterRadiologyUrologyUpper Abdominal SurgeryEndocrine SurgeryDepartment of Immunology, Genetics and PathologyNeurosurgeryHaematologyDepartment of Women's and Children's HealthNeuro-OncologyVascular Biology
In the same journal
Acta Oncologica
Cancer and OncologyUrology and Nephrology

Search outside of DiVA

GoogleGoogle Scholar
Total: 6 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 324 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf