Extending our previous research on the relation between personality and prejudice, we examined, in two studies, the predictive power of Big Five facet scores instead of factor scores using the NEO-PI-R. In Study 1, our results showed that 18 facets were significantly correlated with generalized prejudice – a composite of ethnic prejudice, sexism, homophobia, and prejudice toward people with intellectual disabilities. Stepwise regression analyses showed that the prediction based on facet scores was significantly stronger than that based on factor scores with Agreeableness (A) and Openness (O) as the strongest factor predictors and with Tender-Mindedness (A) and Values (O) as the strongest facet predictors. In Study 2, we tested the robustness of the findings in Study 1 and examined one specific type of prejudice – sexism. The results were quite in line with those of Study 1 and showed that the prediction of sexism based on facet scores was stronger than that based on factor scores. The results are discussed against the background of previous research on the relationship between personality and prejudice, and in the context of the two major approaches to explaining individual differences in prejudice – the personality and the social psychology approach.