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Labeling of aliphatic carboxylic acids using [11C]carbon monoxide
Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Biochemistry and Organic Chemistry, Organic Chemistry II.
Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Biochemistry and Organic Chemistry, Organic Chemistry II.
2006 (English)In: Nature Protocols, ISSN 1754-2189, Vol. 1, no 2, 798-802 p.Article in journal (Refereed) Published
Abstract [en]

Here we present a protocol for labeling aliphatic carboxylic acids with the positron-emitting radionuclide 11C (t1/2 = 20.4 min) at the carboxyl position using [11C]carbon monoxide via photoinitiated free radical-mediated carbonylation. A solution of an alkyl iodide in a homogenous binary organic solvent-water mixture is introduced into a high-pressure photochemical reactor containing [11C]carbon monoxide. Then the reactor contents are pressurized to 40 MPa and irradiated with ultraviolet light for 6 min. The labeled product is purified using HPLC. All manipulations with radioactivity including the labeling synthesis are carried out on an automated Synthia system. In a typical case, 3.19 GBq of purified [1-11C]1,10-decanedicarboxylic acid (with a specific radioactivity of 188 GBq/μmol) can be obtained within 35 min after the end of a 10-μAh bombardment. Compared to previous labeling methods, this protocol is compatible with a wider range of functional groups, utilizes less-sensitive precursors, and is less subject to isotopic dilution.

Place, publisher, year, edition, pages
2006. Vol. 1, no 2, 798-802 p.
National Category
Organic Chemistry
Identifiers
URN: urn:nbn:se:uu:diva-83892DOI: 10.1038/nprot.2006.112ISI: 000251002500039PubMedID: 17406310OAI: oai:DiVA.org:uu-83892DiVA: diva2:111800
Available from: 2006-11-10 Created: 2006-11-10 Last updated: 2011-01-17Bibliographically approved

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Itsenko, OleksiyLångström, Bengt

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