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Quantitative positron emission tomography in brain research
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Radiology. Wallenberg Centre for Molecular and Translational Medicine and the Department of Psychiatry and Neurochemistry, University of Gothenburg, Sweden.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Surgical Sciences, Radiology. Medical Physics, Uppsala University Hospital, Uppsala, Sweden.
Uppsala University, Disciplinary Domain of Humanities and Social Sciences, Faculty of Social Sciences, Department of Psychology. Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.ORCID iD: 0000-0003-2516-9075
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2017 (English)In: Brain Research, ISSN 0006-8993, E-ISSN 1872-6240, Vol. 1670, 220-234 p., S0006-8993(17)30270-6Article, review/survey (Refereed) Published
Abstract [en]

The application of positron emission tomography (PET) in brain research has increased substantially during the past 20 years, and is still growing. PET provides a unique insight into physiological and pathological processes in vivo. In this article we introduce the fundamentals of PET, and the methods available for acquiring quantitative estimates of the parameters of interest. A short introduction to different areas of application is also given, including basic research of brain function and in neurology, psychiatry, drug receptor occupancy studies, and its application in diagnostics of neurodegenerative disorders such as Alzheimer's disease and Parkinson's disease. Our aim is to inform the unfamiliar reader of the underlying basics and potential applications of PET, hoping to inspire the reader into considering how the technique could be of benefit for his or her own research.

Place, publisher, year, edition, pages
2017. Vol. 1670, 220-234 p., S0006-8993(17)30270-6
Keyword [en]
Brain, Diagnostics, Imaging biomarkers, Molecular imaging, Positron emission tomography
National Category
Neurosciences Radiology, Nuclear Medicine and Medical Imaging
Identifiers
URN: urn:nbn:se:uu:diva-326069DOI: 10.1016/j.brainres.2017.06.022ISI: 000407666000024PubMedID: 28652218OAI: oai:DiVA.org:uu-326069DiVA: diva2:1118450
Available from: 2017-06-30 Created: 2017-06-30 Last updated: 2017-12-01Bibliographically approved

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Heurling, KerstinJonasson, MyFrick, AndreasLubberink, Mark

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