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Genetic Diversity and the Efficacy of Purifying Selection across Plant and Animal Species
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Genetics, Plant Ecology and Evolution. Uppsala University, Science for Life Laboratory, SciLifeLab.
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Genetics, Plant Ecology and Evolution. Uppsala University, Science for Life Laboratory, SciLifeLab. Univ Montpellier, CNRS, IRD, Inst Sci Evolut,EPHE,UMR 5554, Montpellier, France..
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Genetics, Plant Ecology and Evolution. Uppsala University, Science for Life Laboratory, SciLifeLab.
2017 (English)In: Molecular biology and evolution, ISSN 0737-4038, E-ISSN 1537-1719, Vol. 34, no 6, p. 1417-1428Article in journal (Refereed) Published
Abstract [en]

A central question in evolutionary biology is why some species have more genetic diversity than others and a no less important question is why selection efficacy varies among species. Although these questions have started to be tackled in animals, they have not been addressed to the same extent in plants. Here, we estimated nucleotide diversity at synonymous, pi(S), and nonsynonymous sites, pi(N), and a measure of the efficacy of selection, the ratio pi(N)/pi(S), in 34 animal and 28 plant species using full genome data. We then evaluated the relationship of nucleotide diversity and selection efficacy with effective population size, the distribution of fitness effect and life history traits. In animals, our data confirm that longevity and propagule size are the variables that best explain the variation in pi(S) among species. In plants longevity also plays a major role as well as mating system. As predicted by the nearly neutral theory of molecular evolution, the log of pi(N)/pi(S) decreased linearly with the log of pi(S) but the slope was weaker in plants than in animals. This appears to be due to a higher mutation rate in long lived plants, and the difference disappears when pi(S) is rescaled by the mutation rate. Differences in the distribution of fitness effect of new mutations also contributed to variation in pi(N)/pi(S) among species.

Place, publisher, year, edition, pages
OXFORD UNIV PRESS , 2017. Vol. 34, no 6, p. 1417-1428
Keywords [en]
effective population size, distribution of fitness effects, purifying selection, life history traits, nearly neutral theory
National Category
Biological Sciences
Identifiers
URN: urn:nbn:se:uu:diva-326224DOI: 10.1093/molbev/msx088ISI: 000402061700010PubMedID: 28333215OAI: oai:DiVA.org:uu-326224DiVA, id: diva2:1119575
Funder
Swedish Research Council FormasSwedish Research CouncilSwedish Foundation for Strategic Research Available from: 2017-07-04 Created: 2017-07-04 Last updated: 2017-07-04Bibliographically approved

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Chen, JunGlemin, SylvainLascoux, Martin

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