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Asymmetric hydrogenation of tri-substituted alkenes with Ir-NHC-thiazole complexes
Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Biochemistry and Organic Chemistry, Organic Chemistry I.
Uppsala University, Disciplinary Domain of Science and Technology, Chemistry, Department of Biochemistry and Organic Chemistry, Organic Chemistry I.
2006 (English)In: Tetrahedron Letters, ISSN 0040-4039, E-ISSN 1359-8562, Vol. 47, no 42, p. 7477-7480Article in journal (Refereed) Published
Abstract [en]

An efficient chiral N-heterocyclic carbene ligand for the Ir-catalyzed asymmetric hydrogenation of largely unfunctionalized tri-substituted olefins has been developed. The Ir-NHC-thiazole catalyst is able to reduce a large variety of substrates with excellent conversions and good enantioselectivities with ee's ranging from 34% to 90%, depending on the geometry around the double bond of the substrates.

Place, publisher, year, edition, pages
2006. Vol. 47, no 42, p. 7477-7480
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Organic Chemistry
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URN: urn:nbn:se:uu:diva-84297DOI: 10.1016/j.tetlet.2006.08.039ISI: 000241063900018OAI: oai:DiVA.org:uu-84297DiVA, id: diva2:112205
Available from: 2006-11-14 Created: 2006-11-14 Last updated: 2017-12-14Bibliographically approved

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Källström, KlasAndersson, Pher

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