Asymmetric hydrogenation of tri-substituted alkenes with Ir-NHC-thiazole complexes
2006 (English)In: Tetrahedron Letters, ISSN 0040-4039, E-ISSN 1873-3581, Vol. 47, no 42, 7477-7480 p.Article in journal (Refereed) Published
An efficient chiral N-heterocyclic carbene ligand for the Ir-catalyzed asymmetric hydrogenation of largely unfunctionalized tri-substituted olefins has been developed. The Ir-NHC-thiazole catalyst is able to reduce a large variety of substrates with excellent conversions and good enantioselectivities with ee's ranging from 34% to 90%, depending on the geometry around the double bond of the substrates.
Place, publisher, year, edition, pages
2006. Vol. 47, no 42, 7477-7480 p.
IdentifiersURN: urn:nbn:se:uu:diva-84297DOI: 10.1016/j.tetlet.2006.08.039ISI: 000241063900018OAI: oai:DiVA.org:uu-84297DiVA: diva2:112205