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On the use of liquid chromatography with radio- and ultraviolet absorbance detection coupled to mass spectrometry for improved sensitivity and selectivity in determination of specific radioactivity of radiopharmaceuticaIs
Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry.
1999 (English)In: JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, ISSN 0731-7085, Vol. 20, no 3, 493-501 p.Article in journal (Refereed) Published
Abstract [en]

Pneumatically assisted electrospray mass spectrometry was evaluated as a complementary detection technique to UV absorbance, for determination of specific radioactivity of tracer molecules to be used in positron emission tomography. Tracers labelled with

Place, publisher, year, edition, pages
PERGAMON-ELSEVIER SCIENCE LTD , 1999. Vol. 20, no 3, 493-501 p.
Keyword [en]
liquid chromatography; mass spectrometry; specific radioacitivity; carbon-11; POSITRON EMISSION TOMOGRAPHY; ATMOSPHERIC-PRESSURE; ELECTROSPRAY-IONIZATION; RHESUS-MONKEY; DOPAMINE-RECEPTORS; HUMAN-BRAIN; PET; BINDING; BIODISTRIBUTION; KINETICS
Identifiers
URN: urn:nbn:se:uu:diva-84866OAI: oai:DiVA.org:uu-84866DiVA: diva2:112774
Note
Addresses: Langstrom B, Univ Uppsala, Inst Chem, Dept Organ Chem, Box 531, S-75121 Uppsala, Sweden. Univ Uppsala, Inst Chem, Dept Organ Chem, S-75121 Uppsala, Sweden. Univ Uppsala, Inst Chem, Dept Analyt Chem, S-75121 Uppsala, Sweden. Quintiles, S-75318Available from: 2008-10-17 Created: 2008-10-17 Last updated: 2011-01-14

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