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Inhibition of the tissue factor factor VIIa complex - Lead optimisation using combinatorial chemistry
Uppsala University.
Uppsala University.
Uppsala University.
Uppsala University.
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1999 (English)In: TETRAHEDRON, Vol. 55, no 19, 6219-6230 p.Other (Other scientific)
Abstract [en]

Following a high throughput screen (HTS) for the inhibition of the tissue factor/factor VIIa complex and the identification of a number of original hits a lead optimisation programme was initiated to improve their potency. This necessitated the developme

Place, publisher, year, pages
PERGAMON-ELSEVIER SCIENCE LTD , 1999. Vol. 55, no 19, 6219-6230 p.
Keyword [en]
amidines; combinatorial; solid phase; library; SOLID-PHASE SYNTHESIS; BLOOD-COAGULATION; TRYPANOTHIONE REDUCTASE; MITSUNOBU REACTION; DERIVATIVES; ACTIVATION; CLEAVAGE
Identifiers
URN: urn:nbn:se:uu:diva-84872OAI: oai:DiVA.org:uu-84872DiVA: diva2:112780
Note
Addresses: Bradley M, Univ Southampton, Dept Chem, Southampton SO17 1BJ, Hants, England. Univ Southampton, Dept Chem, Southampton SO17 1BJ, Hants, England. Pharmacia & Upjohn Inc, Dept Chem, S-75182 Uppsala, Sweden. Novartis Pharmaceut, Dept Chem, HorshaAvailable from: 2008-10-17 Created: 2008-10-17

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