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Identification of CYP3A4 as the major enzyme responsible for 25-hydroxylation of 5 beta-cholestane-3 alpha,7 alpha,12 alpha-triol in human liver microsomes
Uppsala University.
Uppsala University.
1999 (English)In: BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, Vol. 1437, no 1, 46-52 p.Other (Other scientific)
Abstract [en]

Human liver microsomes catalyze an efficient 25-hydroxylation of 5 beta-cholestane-3 alpha,7 alpha, 12 alpha-triol. The hydroxylation is involved in a minor, alternative pathway for side-chain degradation in the biosynthesis of cholic acid. The enzyme re

Place, publisher, year, pages
ELSEVIER SCIENCE BV , 1999. Vol. 1437, no 1, 46-52 p.
Keyword [en]
CYP3A4; 5 beta-cholestane-3 alpha;7 alpha;12 alpha-triol; 25-hydroxylation; BILE-ACIDS; CEREBROTENDINOUS XANTHOMATOSIS; CHOLIC-ACID; BIOSYNTHESIS; CYTOCHROME-P-450; 26-HYDROXYLATION; HYDROXYLATIONS; METABOLISM; MECHANISM; PATHWAY
Identifiers
URN: urn:nbn:se:uu:diva-84895OAI: oai:DiVA.org:uu-84895DiVA: diva2:112803
Note
Addresses: Furster C, Univ Uppsala, Div Biochem, Dept Pharmaceut Biosci, Box 578, S-75123 Uppsala, Sweden. Univ Uppsala, Div Biochem, Dept Pharmaceut Biosci, S-75123 Uppsala, Sweden.Available from: 2008-10-17 Created: 2008-10-17

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