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Column switching in capillary liquid chromatography tandem mass spectrometry for the quantitation of pg/ml concentrations of the free basic drug tolterodine and its active 5-hydroxymethyl metabolite in microliter volumes of plasma
Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Chemistry, Department of Chemistry.
1998 (English)In: JOURNAL OF CHROMATOGRAPHY A, ISSN 0021-9673, Vol. 828, no 1-2, 209-218 p.Article in journal (Refereed) Published
Abstract [en]

A capillary column switching system was developed for the determination of low, unbound concentrations of the basic drug tolterodine and its active 5-hydroxymethyl (5-HM) metabolite in human plasma. Free concentrations of tolterodine and 5-HM at pM and n

Place, publisher, year, edition, pages
1998. Vol. 828, no 1-2, 209-218 p.
Keyword [en]
column switching; ultrafiltration; tolterodine; URINE; SAMPLES
National Category
Analytical Chemistry
Identifiers
URN: urn:nbn:se:uu:diva-84911OAI: oai:DiVA.org:uu-84911DiVA: diva2:112819
Note
Addresses: Markides KE, Univ Uppsala, Inst Chem, Dept Analyt Chem, POB 531, S-75121 Uppsala, Sweden. Univ Uppsala, Inst Chem, Dept Analyt Chem, S-75121 Uppsala, Sweden.Available from: 2005-04-06 Created: 2005-04-06 Last updated: 2011-01-14

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