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MPTP-induced deficits in motor activity: neuroprotective effects of the spintrapping agent, alpha-phenyl-tert-butyl-nitrone (PBN)
Uppsala University.
Uppsala University.
Uppsala University.
1997 (English)In: JOURNAL OF NEURAL TRANSMISSION, ISSN 0300-9564, Vol. 104, no 6-7, 579-592 p.Article in journal (Other scientific) Published
Abstract [en]

In Experiment 1, groups of mice were administered either saline or MPTP (2 x 30 mg/kg, s.c., separated by a 24-hr interval) 30 min after being injected either PBN (15, 50 or 150 mg/kg, s.c., low, medium and high doses, respectively) or L-Deprenyl (0.25 or

Place, publisher, year, edition, pages
SPRINGER-VERLAG WIEN , 1997. Vol. 104, no 6-7, 579-592 p.
Keyword [en]
MPTP; PEN; single; repeated treatment; pre- and post-MPTP; locomotion; rearing; dopamine; hypoactivity; reversal; DA-loss; C57 BL/6; HYDROXYL RADICAL GENERATION; BRAIN MONOAMINE-OXIDASE; PARKINSONS-DISEASE; 1-METHYL-4-PHENYL-1;2;3;6-TETRAHYDROPYRIDINE TRE
URN: urn:nbn:se:uu:diva-85003OAI: oai:DiVA.org:uu-85003DiVA: diva2:112911
Addresses: Fredriksson A, UPPSALA UNIV, DEPT PSYCHIAT, S-75017 UPPSALA, SWEDEN. UPPSALA UNIV, DEPT ENVIRONM TOXICOL, S-75017 UPPSALA, SWEDEN. GOTHENBURG UNIV, DEPT PSYCHOL, GOTHENBURG, SWEDEN.Available from: 2008-10-17 Created: 2008-10-17 Last updated: 2011-01-15

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