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TET2 mutations in B cells of patients affected by angioimmunoblastic T-cell lymphoma
Univ Duisburg Essen, Med Sch, Inst Cell Biol Canc Res, Virchowstr 173, D-45122 Essen, Germany.;Goethe Univ Frankfurt, Med Sch, Dr Senckenberg Inst Pathol, Frankfurt, Germany..
Univ Duisburg Essen, Med Sch, Inst Cell Biol Canc Res, Virchowstr 173, D-45122 Essen, Germany..
Goethe Univ Frankfurt, Med Sch, Dr Senckenberg Inst Pathol, Frankfurt, Germany..
Goethe Univ Frankfurt, Med Sch, Dr Senckenberg Inst Pathol, Frankfurt, Germany..
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2017 (English)In: Journal of Pathology, ISSN 0022-3417, E-ISSN 1096-9896, Vol. 242, no 2, p. 129-133Article in journal (Refereed) Published
Abstract [en]

Angioimmunoblastic T-cell lymphomas (AITLs) frequently carry mutations in the TET2 and IDH2 genes. TET2 mutations represent early genetic lesions as they had already been detected in haematopoietic precursor cells of AITL patients. We show by analysis of whole-tissue sections and microdissected PD1(+) cells that the frequency of TET2-mutated AITL is presumably even higher than reported (12/13 cases in our collection; 92%). In two-thirds of informative AITLs (6/9), a fraction of B cells was also TET2-mutated. Investigation of four AITLs by TET2 and IGHV gene sequencing of single microdissected B cells showed that between 10% and 60% of polyclonal B cells in AITL lymph nodes harboured the identical TET2 mutations of the respective T-cell lymphoma clone. Thus, TET2-mutated haematopoietic precursor cells in AITL patients not only give rise to the T-cell lymphoma but also generate a large population of mutated mature B cells. Future studies will show whether this is a reason why AITL patients frequently also develop B-cell lymphomas. Copyright (C) 2017 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.

Place, publisher, year, edition, pages
WILEY , 2017. Vol. 242, no 2, p. 129-133
Keywords [en]
angioimmunoblastic T-cell lymphoma, B cells, IDH2, somatic mutation, TET2
National Category
Cancer and Oncology
Identifiers
URN: urn:nbn:se:uu:diva-327239DOI: 10.1002/path.4898ISI: 000402909800001PubMedID: 28337768OAI: oai:DiVA.org:uu-327239DiVA, id: diva2:1130123
Available from: 2017-08-08 Created: 2017-08-08 Last updated: 2017-08-08Bibliographically approved

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