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Correlation of response to treatment and HIV genotypic changes during Phase III trials with saquinavir and reverse transcriptase inhibitor combination therapy
Uppsala University.
Uppsala University.
Uppsala University.
Uppsala University.
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1998 (English)In: AIDS, ISSN 0269-9370, Vol. 12, no 12, 1465-1474 p.Article in journal (Other scientific) Published
Abstract [en]

Objectives: Assessment of genotypic change in HIV protease during treatment with saquinavir (SQV) in combination with zidovudine (ZDV) and/or zalcitabine (ddC), to determine the influence of such changes on viral phenotype and response to treatment. Desig

Place, publisher, year, edition, pages
LIPPINCOTT WILLIAMS & WILKINS , 1998. Vol. 12, no 12, 1465-1474 p.
Keyword [en]
HIV protease; genotypic change; therapy; combination; phenotypic change; drug sensitivity; IMMUNODEFICIENCY-VIRUS TYPE-1; PROTEASE INHIBITORS; SEQUENCE DIVERSITY; RESISTANCE; PROTEINASE; INFECTION; VARIANTS; SENSITIVITY; RO-31-8959; MUTATIONS
Identifiers
URN: urn:nbn:se:uu:diva-85132OAI: oai:DiVA.org:uu-85132DiVA: diva2:113040
Note
Addresses: Cammack N, Roche Discovery Welwyn, Dept Virol, 40 Broadwater Rd, Virol 1, Welwyn Garden City AL7 3AY, Herts, England. Roche Discovery Welwyn, Dept Virol, Welwyn Garden City AL7 3AY, Herts, England. Profess Genet Lab, Uppsala, Sweden.Available from: 2008-10-17 Created: 2008-10-17 Last updated: 2011-01-14

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